21
August 2003
Cell biology: Glycolysis and apoptosis linked
Glycolysis (energy-providing glucose breakdown) and apoptosis (programmed cell death) are two major regulators of cell survival. The widely held view is that they are independent pathways, but now a combination of proteomics, genetics and physiological techniques may have changed that picture. BAD protein is an apoptosis inducer associated with BCL2 and BAX, two of the family of Bcl2-encoded proteins that regulate cell survival and cell death in many tissues. BAD has now been found to be a component of an enzyme complex in mouse liver mitochondria that also contains a glucokinase. This complex is necessary to maintain glucose homeostasis and to connect cellular metabolism and apoptosis.
BAD and glucokinase reside in a mitochondrial
complex that integrates glycolysis and apoptosis
NIKA N. DANIAL, COLETTE F. GRAMM, LUCA SCORRANO, CHEN-YU
ZHANG, STEFAN KRAUSS, ANN M. RANGER, SANDEEP ROBERT DATTA, MICHAEL E.
GREENBERG, LAWRENCE J. LICKLIDER, BRADFORD B. LOWELL, STEVEN P. GYGI &
STANLEY J. KORSMEYER
Nature 424, 952–956 (2003); doi:10.1038/nature01825
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Cell biology: Metabolism meets death
JULIAN DOWNWARD
A protein that controls cell death has been found in a complex with a
protein involved in glucose metabolism. Is this a point of contact between
these two crucial cellular processes?
Nature 424, 896–897 (2003); doi:10.1038/424896a
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