8
May 2003
Malaria control: Crucial letter
Resistance to insecticides among mosquito vectors is jeopardizing efforts to control malaria and West Nile virus. In resistant mosquitoes, acetylcholinesterase is insensitive to organophosphates and carbamates. This is now shown to result from a single amino-acid substitution, a GGC glycine codon is replaced by AGC for serine. Identification of this mutation may pave the way to insecticides specifically designed to inhibit mutant acetylcholinesterase.
Comparative genomics: Insecticide resistance in mosquito
vectors
MYL�NE WEILL, GEORGES LUTFALLA, KNUD MOGENSEN,
FABRICE CHANDRE, ARNAUD BERTHOMIEU, CLAIRE BERTICAT, NICOLE PASTEUR, ALEXANDRE
PHILIPS, PHILIPPE FORT & MICHEL RAYMOND
Nature 423, 136–137
(2003); doi:10.1038/423136b
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