1
May 2003
Genomics: Anthrax bacillus genome
The complete genome sequence of the human pathogen Bacillus anthracis is now published, and two groups compare the sequence with that of close relatives Bacillus cereus, sometimes a cause of food poisoning, and Bacillus thuringiensis, an insect pathogen and biotechnology tool. As was widely assumed, many of the important anthrax virulence determinants are found on plasmids, but haemolysins, phospholipases and iron acquisition proteins that might also contribute to virulence are on the chromosomes. These proteins, and various surface proteins that might act as targets for vaccines and drugs, have homologues in B. cereus.
The genome sequence of Bacillus anthracis Ames
and comparison to closely related bacteria
TIMOTHY
D. READ, SCOTT N. PETERSON, NICOLAS TOURASSE, LES W. BAILLIE , IAN T. PAULSEN,
KAREN E. NELSON, HERV� TETTELIN, DERRICK E. FOUTS, JONATHAN A. EISEN, STEVEN R.
GILL, ERIK K. HOLTZAPPLE, OLE ANDREAS ØKSTAD, ERLENDUR HELGASON, JENNIFER
RILSTONE, MARTIN WU, JAMES F. KOLONAY, MAUREEN J. BEANAN, ROBERT J. DODSON, LAUREN
M. BRINKAC, MICHELLE GWINN, ROBERT T. DEBOY, RAMANA MADPU, SEAN C. DAUGHERTY,
A. SCOTT DURKIN, DANIEL H. HAFT, WILLIAM C. NELSON, JEREMY D. PETERSON, MIHAI
POP, HODA M. KHOURI, DIANA RADUNE, JONATHAN L. BENTON, YASMIN MAHAMOUD, LINGXIA
JIANG, IOANA R. HANCE, JANICE F. WEIDMAN, KRISTI J. BERRY, ROGER D. PLAUT, ALEX
M. WOLF, KISHA L. WATKINS, WILLIAM C. NIERMAN, ALYSON HAZEN, ROBIN CLINE, CAROLINE
REDMOND, JOANNE E. THWAITE, OWEN WHITE, STEVEN L. SALZBERG, BRENDAN THOMASON,
ARTHUR M. FRIEDLANDER, THERESA M. KOEHLER, PHILIP C. HANNA, ANNE-BRIT KOLSTØ
& CLAIRE M. FRASER
Nature 423, 81–86 (2003); doi:10.1038/nature01586
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Genome sequence of Bacillus cereus and comparative
analysis with Bacillus anthracis
NATALIA
IVANOVA, ALEXEI SOROKIN, IAIN ANDERSON, NATHALIE GALLERON, BENJAMIN CANDELON,
VINAYAK KAPATRAL, ANAMITRA BHATTACHARYYA, GARY REZNIK, NATALIA MIKHAILOVA, ALLA
LAPIDUS, LIEN CHU, MICHAEL MAZUR, EUGENE GOLTSMAN, NIELS LARSEN, MARK D'SOUZA,
THERESA WALUNAS, YURI GRECHKIN, GORDON PUSCH, ROBERT HASELKORN, MICHAEL FONSTEIN,
S. DUSKO EHRLICH, ROSS OVERBEEK & NIKOS KYRPIDES
Nature 423,
87–91 (2003); doi:10.1038/nature01582
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Genomics: Relative pathogenic values
JULIAN
PARKHILL & COLIN BERRY
The bacterium that causes anthrax has several close
relatives. Comparison of their genome sequences should provide insight into the
biology of these organisms as agents of disease — and of terrorism.
Nature
423, 23–25 (2003); doi:10.1038/423023a
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