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May 2003
Immune diseases: TALL story
TALL-1, a member of the tumour necrosis factor (TNF) family, plays an important role in the immune response by costimulating B lymphocyte proliferation. It is the subject of intense research and patents are being sought relating to the use of TALL-1 (also known as BAFF or BlyS) to treat inflammatory and immune-related diseases including lupus and cancer. The crystal structure of the functional, soluble component of the molecule, sTALL-1, in complexes with two of its receptors, is now reported. The structure reveals a mode of binding very different to that seen in other TNF–receptor complexes.
Ligand-receptor
binding revealed by the TNF family member TALL-1
YINGFANG
LIU, XIA HONG, JOHN KAPPLER , LING JIANG, RONGGUANG ZHANG, LIANGGUO XU, CHEOL-HO
PAN, WESLEY E. MARTIN, ROBERT C. MURPHY, HONG-BING SHU, SHAODONG DAI & GONGYI
ZHANG
Nature 423, 49–56 (2003); doi:10.1038/nature01543
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