14
November 2002
Gene therapy: Pause for thought
A young boy cured of severe combined immune deficiency (SCID) by gene therapy has developed a leukaemia-like condition almost certainly caused by the very treatment that cured him. The hunt is on to discover the intrinsic risks of current methods of gene transfer — and to develop new methods that minimize the risks.
Gene therapy: A tragic setback
ERIKA
CHECK
With one French gene-therapy patient having developed a form of cancer,
a frantic detective effort is under way to determine what went wrong — and
to assess the risks faced by others. Erika Check reports.
Nature 420,
116–118 (2002); doi:10.1038/420116a
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