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August 2002
Genetics: Trans-Europe expression
Chromosome 22, the first human chromosome to be sequenced, is now the subject
of another milestone in population genomics, a high-resolution linkage disequilibrium
map of the complete chromosome. This relates the positions of sequence variations
involved in phenotypes such as disease risk and drug response with neighbouring
markers, and serves as a history of the chromosome in the population studied.
DNA samples were from numerous
Caucasian populations, and the chromosome-level
patterns of variation appear largely invariant across Europe.
A first-generation linkage disequilibrium map of human
chromosome 22
ELISABETH DAWSON, GON�ALO R. ABECASIS,
SUZANNAH BUMPSTEAD, YUAN CHEN, SARAH HUNT, DAVID M. BEARE, JAGJIT PABIAL, THOMAS
DIBLING, EMMA TINSLEY, SUSAN KIRBY, DAVID CARTER, MARIANNA PAPASPYRIDONOS, SIMON
LIVINGSTONE, ROCKY GANSKE, ELIN L�HMUSSAAR, JANA ZERNANT, NEEME T�NISSON, MAIDO
REMM, REEDIK M�GI, TARMO PUURAND, JAAK VILO, ANTS KURG, KATE RICE, PANOS DELOUKAS,
RICHARD MOTT, ANDRES METSPALU, DAVID R. BENTLEY, LON R. CARDON & IAN DUNHAM
Nature 418, 544–548 (2002); doi:10.1038/nature00864
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