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Nature6 June 2002

 nature highlights

Developmental neurobiology: In two minds

Analysis of the human neocortex has revealed two distinct lineages of GABAergic neurons, one of which is not observed in rodents. This could have implications for the evolution of the primate brain. GABA is the inhibitory neurotransmitter in local circuit neurons, and the discovery of this difference between rodents and primates suggests that the changes in the expression pattern of transcription factors in the forebrain may be related to species-specific programs for the generation of local circuits in the forebrain.

letters to nature
Origin of GABAergic neurons in the human neocortex
KRESIMIR LETINIC, ROBERTO ZONCU & PASKO RAKIC
Nature 417, 645–649 (6 June 2002)
| First Paragraph | Full Text | PDF (509 K) |

news and views
Developmental neurobiology: Cortical liars
SEONG-SENG TAN
Inhibitory cells known as interneurons constitute a significant proportion of the neurons in the neocortex of mammalian brains. As far as interneuron origins are concerned, humans may be the odd man out.
Nature 417, 605–606 (6 June 2002)
| Full Text | PDF (79 K) |

6 June 2002 table of contents

  
  © 2002 Nature Publishing Group