9
May 2002
Genomics: Genome of an antibiotics factory
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Streptomyces coelicolor is genetically the most studied member of a group of soil-dwelling bacteria that produce most of the natural antibiotics in medical use. This week sees the publication of the complete genome sequence of this important actinomycete, which boasts the largest number of genes found in any bacterium, in part due to its many differentiated states in a complex environment. Colonies grow blue (coelicolor = 'sky blue colour') and the droplets on the colonies shown on the cover are accumulations of some of its many secondary metabolites.
Complete genome sequence of the model actinomycete Streptomyces
coelicolor A3(2)
S. D. BENTLEY, K. F. CHATER,
A.-M. CERDE�O-T�RRAGA, G. L. CHALLIS, N. R. THOMSON, K. D. JAMES, D. E. HARRIS,
M. A. QUAIL, H. KIESER, D. HARPER, A. BATEMAN, S. BROWN, G. CHANDRA, C. W. CHEN,
M. COLLINS, A. CRONIN, A. FRASER, A. GOBLE, J. HIDALGO, T. HORNSBY, S. HOWARTH,
C.-H. HUANG, T. KIESER, L. LARKE, L. MURPHY, K. OLIVER, S. O'NEIL, E. RABBINOWITSCH,
M.-A. RAJANDREAM, K. RUTHERFORD, S. RUTTER, K. SEEGER, D. SAUNDERS, S. SHARP,
R. SQUARES, S. SQUARES, K. TAYLOR, T. WARREN, A. WIETZORREK, J. WOODWARD, B. G.
BARRELL, J. PARKHILL & D. A. HOPWOOD
Nature 417, 141–147
(9 May 2002)
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