Salmonella enterica: Two of a kind

The complete genome sequences of two variants of Salmonella enterica are published this week. Serovar Typhi (or S. typhi) is the cause of typhoid fever and serovar Typhimurium LT2 (S. typhimurium) can lead to human gastroenteritis. Comparisons of these sequences with each other and with E. coli reveal details of plasmids involved in multidrug resistance and a pathogenicity plasmid remarkably like one in the plague pathogen, Yersinia pestis.

Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
J. PARKHILL, G. DOUGAN, K. D. JAMES, N. R. THOMSON, D. PICKARD, J. WAIN, C. CHURCHER, K. L. MUNGALL, S. D. BENTLEY, M. T. G. HOLDEN, M. SEBAIHIA, S. BAKER, D. BASHAM, K. BROOKS, T. CHILLINGWORTH, P. CONNERTON, A. CRONIN, P. DAVIS, R. M. DAVIES, L. DOWD, N. WHITE, J. FARRAR, T. FELTWELL, N. HAMLIN, A. HAQUE, T. T. HIEN, S. HOLROYD, K. JAGELS, A. KROGH, T. S. LARSEN, S. LEATHER, S. MOULE, P. Ó'GAORA, C. PARRY, M. QUAIL, K. RUTHERFORD, M. SIMMONDS, J. SKELTON, K. STEVENS, S. WHITEHEAD & B. G. BARRELL
Nature 413, 848-852 (25 October 2001)
| First Paragraph | Full Text | PDF (0.9 M) | Supplementary Information |

Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
MICHAEL MCCLELLAND, KENNETH E. SANDERSON, JOHN SPIETH, SANDRA W. CLIFTON, PHIL LATREILLE, LAURA COURTNEY, STEFFEN PORWOLLIK, JOHAR ALI, MIKE DANTE, FEIYU DU, SHUNFANG HOU, DAN LAYMAN, SHAWN LEONARD, CHRISTINE NGUYEN, KELSI SCOTT, ANDREA HOLMES, NEENU GREWAL, ELIZABETH MULVANEY, ELLEN RYAN, HUI SUN, LILIANA FLOREA, WEBB MILLER, TAMBERLYN STONEKING, MICHAEL NHAN, ROBERT WATERSTON & RICHARD K. WILSON
Nature 413, 852-856 (25 October 2001)
| First Paragraph | Full Text | PDF (309 K) | Supplementary Information |

25 October 2001 table of contents