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A screen utilizing an environmental DNA library in Escherichia coli is used to identify Brig1, a previously unknown anti-phage defence system with homologues across distinct clades of bacteria.
Genomic studies of Heliconius butterflies provide evidence that Heliconius elevatus is a hybrid species, and that its speciation was driven by introgression of traits from Heliconius melpomene into the other parent, an ancestor of Heliconius pardalinus.
We propose a model for a sequential, multistep activation mechanism of metabotropic glutamate receptor subtype 5, including a series of structures in lipid nanodiscs, from inactive to fully active, with agonist-bound intermediate states.
Analysis of projected sub-national damages from temperature and precipitation show an income reduction of 19% of the world economy within the next 26 years independent of future emission choices.
Challenging the belief that sympathetic ganglia are an innovation of jawed vertebrates, a study reports the presence of sympathetic neurons in an extant jawless vertebrate, the sea lamprey Petromyzon marinus.
Human genetic evidence increases the success rate of drugs from clinical development to approval but we are still far from reaching peak genetic insights to aid the discovery of targets for more effective drugs.
Using observations of double-difference relocated earthquakes in a local three-dimensional velocity model for Ecuador, a detailed image of seismicity is created, forming the base for more realistic models of earthquake rupture, slip and hazard in subduction zones.
Analysis of a global dataset reveals spatiotemporal patterns of marine plankton and their biogeographical responses during climatic and environmental changes across the Cenozoic era.
A study investigates subcellular, single-cell and network-level comunication within the astrocyte network in response to the two major neurotransmitter inputs.
Near-field radiative heat transfer between two coplanar silicon carbide membranes in close proximity is enhanced by the electromagnetic corner and edge modes.
Lipopolysaccharide-induced breakdown of the blood–brain barrier requires activation of GSDMD-mediated plasma membrane permeabilization and pyroptosis in brain endothelial cells.
Analysis of the energy budget of a sample of 54 well-observed stripped-envelope supernovae of all sub-types shows statistically significant, largely model-independent, observational evidence for a non-radioactive power source in most of them.
Datasets from in situ warming experiments across 28 arctic and alpine tundra sites covering a span of less than 1 year up to 25 years show the importance of local soil conditions and warming-induced changes therein for future climatic impacts on ecosystem respiration.
Measurements of fly muscle activity using a genetically encoded calcium indicator and high-speed imaging of wing movement were used to construct a model of the insect wing hinge and the role of steering muscles in flight control.
Research published in Nature shows that surface-enhanced Raman spectroscopy carried out with colloids can quantify a range of molecules down to concentrations at the femtomolar level.
Streptomyces are discovered to produce antibacterial protein complexes that selectively inhibit the hyphal growth of related species, a function distinct from that of the small-molecule antibiotics they are known for.
The trapping of triply charged 229mTh3+ is described and its nuclear decay half-life determined, showing useful properties for the development of a nuclear clock and applications in the search for new physics.
