Table of Contents

Volume 551 Number 7682 pp541-658

30 November 2017

About the cover

The cover image shows the muscle fibre network of the planarian Schmidtea mediterranea. Planarian muscle is host to the expression of many of the genes that help to direct where regenerating cells are positioned, a crucial aspect for properly controlling the regeneration of missing body parts. Previous work has identified position control genes but how they exert their effects has remained unclear. In this issue, Peter Reddien and his colleagues show that the regeneration of different types of muscle fibres is controlled by different transcription factors: myoD is needed to regenerate longitudinal fibres, whereas nkx1-1 is needed for the formation of circular fibres. They find that loss of longitudinal fibres leads to complete regeneration failure, whereas loss of circular fibres results in two heads regenerating instead of one. As a result, the authors suggest that different muscle types have distinct roles in orchestrating regeneration through controlling wound signalling and patterning. Cover image: M. Lucila Scimone and Kutay Deniz Atabay

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