今週号

Volume 550 Number 7675 pp158-294

12 October 2017

表紙について

The GTEx (Genotype-Tissue Expression) Consortium has established a reference catalogue and associated tissue biobank for gene-expression levels across individuals for diverse tissues of the human body, with a broad sampling of normal, non-diseased human tissues from postmortem donors. In an Article, the consortium presents the deepest survey of gene expression across multiple tissues and individuals to date, encompassing 7,051 samples from 449 donors across 44 human tissues. They characterize the relationship between genetic variation and gene expression across tissues and individuals, and find that most genes are regulated by genetic variation near to the affected gene. In accompanying Letters, Alexis Battle, Stephen Montgomery and their colleagues examine the impact of rare genetic variation on gene expression across human tissues. Daniel MacArthur and his team systematically survey the landscape of X chromosome inactivation in human tissues. And Jin Billy Li and his colleagues provide a comprehensive cross-species analysis of adenosine-to-inosine RNA editing in mammals. In an accompanying News & Views, Michelle Ward and Yoav Gilad put the latest results in context and discuss how these findings are helping to crack the regulatory code of the human genome. Cover image: Concept design: Christine A. Dahl. Graphics: Norm Cyr, Science Illustrator, Department of Pathology, Stanford Medicine

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    • Taru Tukiainen
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    • Laura Gauthier
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