Table of Contents

Volume 550 Number 7674 pp7-150

5 October 2017

About the cover

The cover is a coloured scanning electron micrograph of various oral bacteria. The oral cavity was among six key body sites that formed a major focus in the work to expand the Human Microbiome Project reported on in this issue. Published in 2012, the Human Microbiome Project sampled 18 different body sites to provide a broad overview of the human microbiome in healthy individuals. Curtis Huttenhower and his colleagues have now extended this work to present 1,631 new metagenomes and multiple time points in 265 individuals, looking in particular at six sites, including the nostrils, mouth and gut. Using a combination of strain profiling, species-level metagenomic functional profiling and longitudinal analyses, the study provides deeper insights into human microbial communities, providing an important resource to further our understanding about what constitutes a "healthy" microbiota. Image courtesy: SPL/Getty

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    spotlight: Big science in a small country


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    • Expanding and reprogramming the genetic code

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    • Strains, functions and dynamics in the expanded Human Microbiome Project

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      • A. Brantley Hall
      • Arthur Brady
      • Heather H. Creasy
      • Carrie McCracken
      • Michelle G. Giglio
      • Daniel McDonald
      • Eric A. Franzosa
      • Rob Knight
      • Owen White
      • Curtis Huttenhower

      Updates from the Human Microbiome Project analyse the largest known body-wide metagenomic profile of human microbiome personalization.

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      • Sissy E. Wamaitha
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      • Min Dong
      • Xuhui Huang
      • Rongsheng Jin
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      The detection and simulation of a type Ia supernova with an early, red flash suggests that it formed through detonation of the helium shell of a white dwarf, rather than by collision of the ejecta with a companion star or by merging with another white dwarf.

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      • Margaret R. Metz
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      Vertebrate genomes contain fewer CG dinucleotides than would be expected by chance, and this pattern is mimicked by many viruses; HIV-1 derivatives mutated to contain more CG dinucleotides are targeted by the human antiviral protein ZAP, suggesting that CG suppression has evolved in viruses to evade recognition.

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      • Ruth L. Martin
      • Maricel Torrent
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      • J. William Langston
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      • Philip A. Cole
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      • Michael R. Michaelides
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