Volume 547 Number 7662 pp137-252

13 July 2017


The cover image shows a paired helical filament of tau protein, which is the major component of tangles in Alzheimer’s disease. Tau filaments make up the protein inclusions seen inside nerve cells in the brains of people with many neurodegenerative conditions, including Alzheimer’s. In this issue, Sjors Scheres, Michel Goedert and their colleagues reveal the first high-resolution structures of the two forms of tau filaments in Alzheimer’s disease. The filaments were isolated from the brain of an individual with Alzheimer’s and imaged using cryo-electron microscopy. In both forms, the individual tau proteins form C shapes (white and blue), which stack together to form filaments. The high-resolution structures of these filaments may help the development of novel diagnostics and therapeutic compounds. Cover image: Thomas G. Martin

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