Table of Contents

Volume 547 Number 7662 pp137-252

13 July 2017

About the cover

The cover image shows a paired helical filament of tau protein, which is the major component of tangles in Alzheimer’s disease. Tau filaments make up the protein inclusions seen inside nerve cells in the brains of people with many neurodegenerative conditions, including Alzheimer’s. In this issue, Sjors Scheres, Michel Goedert and their colleagues reveal the first high-resolution structures of the two forms of tau filaments in Alzheimer’s disease. The filaments were isolated from the brain of an individual with Alzheimer’s and imaged using cryo-electron microscopy. In both forms, the individual tau proteins form C shapes (white and blue), which stack together to form filaments. The high-resolution structures of these filaments may help the development of novel diagnostics and therapeutic compounds. Cover image: Thomas G. Martin

This Week



World View

  • Kill the myth of the miracle machine

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Research Highlights


Seven Days


News in Focus


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Books and Arts

  • Information technology: A digital genius at play

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    • Review of A Mind at Play: How Claude Shannon Invented the Information Age
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  • History: Science lessons from the Gulag

    Asif Siddiqi examines a biography of a Soviet meteorologist who taught his daughter from prison.

    • Review of Stalin's Meteorologist: One Man's Untold Story of Love, Life and Death
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  • Books in brief

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naturejobs job listings and advertising features


  • Legs-11

    Meet the home help.

    • Hugh Cartwright


Brief Communications Arising

  • Conflicting evidence for ferroelectricity

    • Gabriele D’Avino
    • Manuel Souto
    • Matteo Masino
    • Jonas K. H. Fischer
    • Imma Ratera
    • Xavier Fontrodona
    • Gianluca Giovannetti
    • Matthieu J. Verstraete
    • Anna Painelli
    • Peter Lunkenheimer
    • Jaume Veciana
    • Alberto Girlando
  • Tayi et al. reply

    • Alok S. Tayi
    • Alexander K. Shveyd
    • Andrew C.-H. Sue
    • Jodi M. Szarko
    • Brian S. Rolczynski
    • Dennis Cao
    • T. Jackson Kennedy
    • Amy A. Sarjeant
    • Charlotte L. Stern
    • Walter F. Paxton
    • Wei Wu
    • Sanjeev K. Dey
    • Albert C. Fahrenbach
    • Jeffrey R. Guest
    • Hooman Mohseni
    • Lin X. Chen
    • Kang L. Wang
    • J. Fraser Stoddart
    • Samuel I. Stupp
  • Overestimate of committed warming

    • Gavin A. Schmidt
    • Jeff Severinghaus
    • Ayako Abe-Ouchi
    • Richard B. Alley
    • Wallace Broecker
    • Ed Brook
    • David Etheridge
    • Kenji Kawamura
    • Ralph F. Keeling
    • Margaret Leinen
    • Kate Marvel
    • Thomas F. Stocker


  • Fine-mapping inflammatory bowel disease loci to single-variant resolution

    • Hailiang Huang
    • Ming Fang
    • Luke Jostins
    • Maša Umićević Mirkov
    • Gabrielle Boucher
    • Carl A. Anderson
    • Vibeke Andersen
    • Isabelle Cleynen
    • Adrian Cortes
    • François Crins
    • Mauro D’Amato
    • Valérie Deffontaine
    • Julia Dmitrieva
    • Elisa Docampo
    • Mahmoud Elansary
    • Kyle Kai-How Farh
    • Andre Franke
    • Ann-Stephan Gori
    • Philippe Goyette
    • Jonas Halfvarson
    • Talin Haritunians
    • Jo Knight
    • Ian C. Lawrance
    • Charlie W. Lees
    • Edouard Louis
    • Rob Mariman
    • Theo Meuwissen
    • Myriam Mni
    • Yukihide Momozawa
    • Miles Parkes
    • Sarah L. Spain
    • Emilie Théâtre
    • Gosia Trynka
    • Jack Satsangi
    • Suzanne van Sommeren
    • Severine Vermeire
    • Ramnik J. Xavier
    • International Inflammatory Bowel Disease Genetics Consortium
    • Rinse K. Weersma
    • Richard H. Duerr
    • Christopher G. Mathew
    • John D. Rioux
    • Dermot P. B. McGovern
    • Judy H. Cho
    • Michel Georges
    • Mark J. Daly
    • Jeffrey C. Barrett

    Results of fine-mapping 94 inflammatory bowel disease loci using high-density genotyping in 67,852 individuals and several new fine-mapping methods.

  • The extracellular matrix protein agrin promotes heart regeneration in mice

    • Elad Bassat
    • Yara Eid Mutlak
    • Alex Genzelinakh
    • Ilya Y. Shadrin
    • Kfir Baruch Umansky
    • Oren Yifa
    • David Kain
    • Dana Rajchman
    • John Leach
    • Daria Riabov Bassat
    • Yael Udi
    • Rachel Sarig
    • Irit Sagi
    • James F. Martin
    • Nenad Bursac
    • Shenhav Cohen
    • Eldad Tzahor

    The extracellular matrix protein agrin promotes cardiac regeneration in adult mice after myocardial infarction; it modulates cardiac differentiation and proliferation by interacting with the dystrophin–glycoprotein complex, Yap and ERK-mediated signalling.


  • The pyrite-type high-pressure form of FeOOH

    • Masayuki Nishi
    • Yasuhiro Kuwayama
    • Jun Tsuchiya
    • Taku Tsuchiya

    The pyrite-type high-pressure form of FeOOH is predicted from first principles, and found experimentally to be stable under the conditions at the base of the mantle, with implications for transport of water within Earth’s deep interior.

  • Pre-oral gut contributes to facial structures in non-teleost fishes

    • Martin Minarik
    • Jan Stundl
    • Peter Fabian
    • David Jandzik
    • Brian D. Metscher
    • Martin Psenicka
    • David Gela
    • Adriana Osorio-Pérez
    • Lenin Arias-Rodriguez
    • Ivan Horácek
    • Robert Cerny

    In contrast to the prevailing belief that the gut begins with the mouth and continues backwards from there, this work shows that substantial areas of the faces of ray-finned fishes originate from the pre-oral gut or endoderm.

  • Nutrient sensing modulates malaria parasite virulence

    • Liliana Mancio-Silva
    • Ksenija Slavic
    • Margarida T. Grilo Ruivo
    • Ana Rita Grosso
    • Katarzyna K. Modrzynska
    • Iset Medina Vera
    • Joana Sales-Dias
    • Ana Rita Gomes
    • Cameron Ross MacPherson
    • Pierre Crozet
    • Mattia Adamo
    • Elena Baena-Gonzalez
    • Rita Tewari
    • Manuel Llinás
    • Oliver Billker
    • Maria M. Mota

    Malaria parasites use a sensing mechanism to moderate their growth in response to the nutrient content of their host.

  • An immunogenic personal neoantigen vaccine for patients with melanoma

    • Patrick A. Ott
    • Zhuting Hu
    • Derin B. Keskin
    • Sachet A. Shukla
    • Jing Sun
    • David J. Bozym
    • Wandi Zhang
    • Adrienne Luoma
    • Anita Giobbie-Hurder
    • Lauren Peter
    • Christina Chen
    • Oriol Olive
    • Todd A. Carter
    • Shuqiang Li
    • David J. Lieb
    • Thomas Eisenhaure
    • Evisa Gjini
    • Jonathan Stevens
    • William J. Lane
    • Indu Javeri
    • Kaliappanadar Nellaiappan
    • Andres M. Salazar
    • Heather Daley
    • Michael Seaman
    • Elizabeth I. Buchbinder
    • Charles H. Yoon
    • Maegan Harden
    • Niall Lennon
    • Stacey Gabriel
    • Scott J. Rodig
    • Dan H. Barouch
    • Jon C. Aster
    • Gad Getz
    • Kai Wucherpfennig
    • Donna Neuberg
    • Jerome Ritz
    • Eric S. Lander
    • Edward F. Fritsch
    • Nir Hacohen
    • Catherine J. Wu

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    • Evelyna Derhovanessian
    • Matthias Miller
    • Björn-Philipp Kloke
    • Petra Simon
    • Martin Löwer
    • Valesca Bukur
    • Arbel D. Tadmor
    • Ulrich Luxemburger
    • Barbara Schrörs
    • Tana Omokoko
    • Mathias Vormehr
    • Christian Albrecht
    • Anna Paruzynski
    • Andreas N. Kuhn
    • Janina Buck
    • Sandra Heesch
    • Katharina H. Schreeb
    • Felicitas Müller
    • Inga Ortseifer
    • Isabel Vogler
    • Eva Godehardt
    • Sebastian Attig
    • Richard Rae
    • Andrea Breitkreuz
    • Claudia Tolliver
    • Martin Suchan
    • Goran Martic
    • Alexander Hohberger
    • Patrick Sorn
    • Jan Diekmann
    • Janko Ciesla
    • Olga Waksmann
    • Alexandra-Kemmer Brück
    • Meike Witt
    • Martina Zillgen
    • Andree Rothermel
    • Barbara Kasemann
    • David Langer
    • Stefanie Bolte
    • Mustafa Diken
    • Sebastian Kreiter
    • Romina Nemecek
    • Christoffer Gebhardt
    • Stephan Grabbe
    • Christoph Höller
    • Jochen Utikal
    • Christoph Huber
    • Carmen Loquai
    • Özlem Türeci

    The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma.

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  • Allelic reprogramming of 3D chromatin architecture during early mammalian development

    • Zhenhai Du
    • Hui Zheng
    • Bo Huang
    • Rui Ma
    • Jingyi Wu
    • Xianglin Zhang
    • Jing He
    • Yunlong Xiang
    • Qiujun Wang
    • Yuanyuan Li
    • Jing Ma
    • Xu Zhang
    • Ke Zhang
    • Yang Wang
    • Michael Q. Zhang
    • Juntao Gao
    • Jesse R. Dixon
    • Xiaowo Wang
    • Jianyang Zeng
    • Wei Xie

    A low-input Hi-C method is used to show that chromatin organization is markedly relaxed in pre-implantation mouse embryos after fertilization and that the subsequent maturation of 3D chromatin architecture is surprisingly slow.

  • Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

    • Adam G. Larson
    • Daniel Elnatan
    • Madeline M. Keenen
    • Michael J. Trnka
    • Jonathan B. Johnston
    • Alma L. Burlingame
    • David A. Agard
    • Sy Redding
    • Geeta J. Narlikar

    Phosphorylation or DNA binding promotes the physical partitioning of HP1α out of a soluble aqueous phase into droplets, suggesting that the repressive action of heterochromatin may in part be mediated by the phase separation of HP1.

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