Volume 547 Number 7661 pp5-132

6 July 2017


In this week’s special issue, Nature zeroes in on that most basic element of life: the cell. Technological advances are powering analyses previously impossible at the single-cell level. As a result, researchers are at last starting to chart how many different types of cell exist in complex organisms, what they do and how they change during development. Efforts to trace cell lineage are examined in a News Feature (page 20), along with a profile of Aviv Regev (page 24), who is spearheading an effort to catalogue every kind of cell in the human body. Elsewhere, researchers explore how the genome is packaged in a mouse cell throughout the division cycle (page 61) and what this might mean for examining genome interactions in 3D (page 34). And Amir Giladi and Ido Amit discuss how a focus on immune cells might aid our ability to combat diseases such as cancer (page 27). A Careers interview explores the reasons for making the move into single-cell analysis (page 129), and Toolbox takes a look at how best to probe the data being generated as the field expands (page 125). Cover illustration by Jasiek Krzysztofiak/Nature; Images: Morphart Creation/Shutterstock, Jezper/Shutterstock

This Week



World View


Research Highlights


Seven Days


News in Focus


  • Single-cell biology

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    Analyses of life's most basic elements promise to improve therapies and provide insights into some of the most fundamental processes in biology.

  • How to build a human cell atlas

    No Alt text available for this image

    Aviv Regev is a maven of hard-core biological analyses. Now she is part of an effort to map every cell in the human body.

    • Anna Nowogrodzki


  • Immunology, one cell at a time

    Analysing the DNA, RNA and protein of single cells is transforming our understanding of the immune system, say Amir Giladi and Ido Amit.

Books and Arts

  • Cybersecurity: The cold war online

    Steven Aftergood weighs up an analysis of the fierce conflict destabilizing the Internet.

    • Review of The Darkening Web: The War for Cyberspace
      Alexander Klimburg
  • Books in brief

    Barbara Kiser reviews five of the week's best science picks.






naturejobs job listings and advertising features






Brief Communications Arising



  • 古気候学 : 完新世における暖水の流入によって生じた西南極氷床の後退

    • Claus-Dieter Hillenbrand
    • James A. Smith
    • David A. Hodell
    • Mervyn Greaves
    • Christopher R. Poole
    • Sev Kender
    • Mark Williams
    • Thorbjテクrn Joest Andersen
    • Patrycja E. Jernas
    • Henry Elderfield
    • Johann P. Klages
    • Stephen J. Roberts
    • Karsten Gohl
    • Robert D. Larter
    • Gerhard Kuhn

    During the early Holocene epoch窶蚤nd since the 1940s窶牌ariations in Southern Hemisphere westerly winds controlled the upwelling of Circumpolar Deep Water and seemingly ice-sheet retreat in West Antarctica.

    See also
  • 気候科学 : 気候変動が南極の露岩生息地の拡大を進行させる

    • Jasmine R. Lee
    • Ben Raymond
    • Thomas J. Bracegirdle
    • Iadine Chadティs
    • Richard A. Fuller
    • Justine D. Shaw
    • Aleks Terauds

    Permanently ice-free areas, home to almost all of Antarctica窶冱 biodiversity, are projected, in the worst case, to expand by over 17,000窶洩m2 as a result of climate change by the end of this century, with potentially deleterious consequences for the continent窶冱 biodiversity.

  • がんゲノミクス : 乳がんにおいて頻発する機能調節変異

    • Esther Rheinbay
    • Prasanna Parasuraman
    • Jonna Grimsby
    • Grace Tiao
    • Jesse M. Engreitz
    • Jaegil Kim
    • Michael S. Lawrence
    • Amaro Taylor-Weiner
    • Sergio Rodriguez-Cuevas
    • Mara Rosenberg
    • Julian Hess
    • Chip Stewart
    • Yosef E. Maruvka
    • Petar Stojanov
    • Maria L. Cortes
    • Sara Seepo
    • Carrie Cibulskis
    • Adam Tracy
    • Trevor J. Pugh
    • Jesse Lee
    • Zongli Zheng
    • Leif W. Ellisen
    • A. John Iafrate
    • Jesse S. Boehm
    • Stacey B. Gabriel
    • Matthew Meyerson
    • Todd R. Golub
    • Jose Baselga
    • Alfredo Hidalgo-Miranda
    • Toshi Shioda
    • Andre Bernards
    • Eric S. Lander
    • Gad Getz

    High-depth sequencing of targeted regions in primary breast cancer identifies mutated promoter elements with recurrent mutations at specific and/or nearby bases, suggesting selection of certain non-coding events.

    See also
  • 生物物理学 : β 2 AR–Gタンパク質活性化におけるリガンドの有効性の一分子解析

    • G. Glenn Gregorio
    • Matthieu Masureel
    • Daniel Hilger
    • Daniel S. Terry
    • Manuel Juette
    • Hong Zhao
    • Zhou Zhou
    • Jose Manuel Perez-Aguilar
    • Maria Hauge
    • Signe Mathiasen
    • Jonathan A. Javitch
    • Harel Weinstein
    • Brian K. Kobilka
    • Scott C. Blanchard

    Single-molecule FRET imaging provides insights into the allosteric link between the ligand-binding and G-protein nucleotide-binding pockets of the ホイ2 adrenergic receptor (ホイ2AR) and improved understanding of the G-protein activation mechanism.




  • Addendum: Immune clearance of highly pathogenic SIV infection

    • Scott G. Hansen
    • Michael Piatak
    • Abigail B. Ventura
    • Colette M. Hughes
    • Roxanne M. Gilbride
    • Julia C. Ford
    • Kelli Oswald
    • Rebecca Shoemaker
    • Yuan Li
    • Matthew S. Lewis
    • Awbrey N. Gilliam
    • Guangwu Xu
    • Nathan Whizin
    • Benjamin J. Burwitz
    • Shannon L. Planer
    • John M. Turner
    • Alfred W. Legasse
    • Michael K. Axthelm
    • Jay A. Nelson
    • Klaus Frテシh
    • Jonah B. Sacha
    • Jacob D. Estes
    • Brandon F. Keele
    • Paul T. Edlefsen
    • Jeffrey D. Lifson
    • Louis J. Picker