Volume 546 Number 7659 pp451-570

22 June 2017


The cover shows an artist’s impression of the Jupiter-like gas giant KELT-9b (bottom) in orbit around the massive star KELT-9. In this issue, Scott Gaudi, Keivan Stassun and their colleagues report the discovery of KELT-9b and reveal it to be one of the hottest exoplanets so far identified. Its dayside surface temperature is about 4,600 K — hotter than most stars, and hot enough to vaporize its atmosphere and to dissociate any molecules into their constituent atoms. The planet is nearly three times more massive than Jupiter but only half as dense. It takes roughly 1.5 days to orbit its host star, and, because it is constantly being blasted with high levels of ultraviolet radiation, it may be shedding a tail of material much like a comet. The rate of ablation may be sufficient for KELT-9b to evaporate completely before its host star reaches the end of its life — assuming that the star doesn ’t grow and engulf the planet first. As only the seventh ‘hot Jupiter’ to be found orbiting a hot A-type star, KELT-9b should help deepen understanding of planetary systems around massive stars, the authors say. Cover image: NASA/JPL-Caltech/R. Hurt (IPAC)

This Week



World View


Research Highlights


News in Focus




Books and Arts





Career Briefs


naturejobs job listings and advertising features



outline: Eardrum regeneration

Produced with support from:



Brief Communication Arising

  • Zanos et al. reply

    • Panos Zanos
    • Ruin Moaddel
    • Patrick J. Morris
    • Polymnia Georgiou
    • Jonathan Fischell
    • Greg I. Elmer
    • Manickavasagom Alkondon
    • Peixiong Yuan
    • Heather J. Pribut
    • Nagendra S. Singh
    • Katina S. S. Dossou
    • Yuhong Fang
    • Xi-Ping Huang
    • Cheryl L. Mayo
    • Edson X. Albuquerque
    • Scott M. Thompson
    • Craig J. Thomas
    • Carlos A. Zarate
    • Todd D. Gould


  • 気候科学 : 火山噴火に起因するエアロゾルと雲の相互作用に関する強い制約条件

    • Florent F. Malavelle
    • Jim M. Haywood
    • Andy Jones
    • Andrew Gettelman
    • Lieven Clarisse
    • Sophie Bauduin
    • Richard P. Allan
    • Inger Helene H. Karset
    • Jテウn Egill Kristjテ。nsson
    • Lazaros Oreopoulos
    • Nayeong Cho
    • Dongmin Lee
    • Nicolas Bellouin
    • Olivier Boucher
    • Daniel P. Grosvenor
    • Ken S. Carslaw
    • Sandip Dhomse
    • Graham W. Mann
    • Anja Schmidt
    • Hugh Coe
    • Margaret E. Hartley
    • Mohit Dalvi
    • Adrian A. Hill
    • Ben T. Johnson
    • Colin E. Johnson
    • Jeff R. Knight
    • Fiona M. O窶僂onnor
    • Daniel G. Partridge
    • Philip Stier
    • Gunnar Myhre
    • Steven Platnick
    • Graeme L. Stephens
    • Hanii Takahashi
    • Thorvaldur Thordarson

    Investigations of an Icelandic volcanic eruption confirm that sulfate aerosols caused a discernible yet transient brightening effect, as predicted, but their effect on the liquid water path was unexpectedly negligible.

    See also
  • 構造生物学 : ヒト多剤輸送体ABCG2の構造

    • Nicholas M. I. Taylor
    • Ioannis Manolaridis
    • Scott M. Jackson
    • Julia Kowal
    • Henning Stahlberg
    • Kaspar P. Locher

    The structure of human ABCG2 bound to an inhibitory antibody using cryo-electron microscopy, representing the first high-resolution structural data of a human multidrug transporter.


  • 天文学 : 初期宇宙において活動をやめた大質量の円盤銀河

    • Sune Toft
    • Johannes Zabl
    • Johan Richard
    • Anna Gallazzi
    • Stefano Zibetti
    • Moire Prescott
    • Claudio Grillo
    • Allison W. S. Man
    • Nicholas Y. Lee
    • Carlos Gテウmez-Guijarro
    • Mikkel Stockmann
    • Georgios Magdis
    • Charles L. Steinhardt

    When the Universe was just 3 billion years old, half of the most massive galaxies had already ceased star formation, and such a galaxy has now been observed using gravitational lensing, unexpectedly turning out to be a compact, fast-spinning disk galaxy rather than a proto-bulge galaxy.

  • 天文学 : 大質量高温中心星からの極端紫外線照射を受けている巨大惑星

    • B. Scott Gaudi
    • Keivan G. Stassun
    • Karen A. Collins
    • Thomas G. Beatty
    • George Zhou
    • David W. Latham
    • Allyson Bieryla
    • Jason D. Eastman
    • Robert J. Siverd
    • Justin R. Crepp
    • Erica J. Gonzales
    • Daniel J. Stevens
    • Lars A. Buchhave
    • Joshua Pepper
    • Marshall C. Johnson
    • Knicole D. Colon
    • Eric L. N. Jensen
    • Joseph E. Rodriguez
    • Valerio Bozza
    • Sebastiano Calchi Novati
    • Giuseppe D窶僊go
    • Mary T. Dumont
    • Tyler Ellis
    • Clement Gaillard
    • Hannah Jang-Condell
    • David H. Kasper
    • Akihiko Fukui
    • Joao Gregorio
    • Ayaka Ito
    • John F. Kielkopf
    • Mark Manner
    • Kyle Matt
    • Norio Narita
    • Thomas E. Oberst
    • Phillip A. Reed
    • Gaetano Scarpetta
    • Denice C. Stephens
    • Rex R. Yeigh
    • Roberto Zambelli
    • B. J. Fulton
    • Andrew W. Howard
    • David J. James
    • Matthew Penny
    • Daniel Bayliss
    • Ivan A. Curtis
    • D. L. DePoy
    • Gilbert A. Esquerdo
    • Andrew Gould
    • Michael D. Joner
    • Rudolf B. Kuhn
    • Jonathan Labadie-Bartz
    • Michael B. Lund
    • Jennifer L. Marshall
    • Kim K. McLeod
    • Richard W. Pogge
    • Howard Relles
    • Christopher Stockdale
    • T. G. Tan
    • Mark Trueblood
    • Patricia Trueblood

    The giant planet KELT-9b has a dayside temperature of about 4,600窶卯, which is sufficiently high to dissociate molecules and to evaporate its atmosphere, owing to its hot stellar host.

  • 植物科学 : 単一分子技術によって改良されたトウモロコシの参照ゲノム open

    • Yinping Jiao
    • Paul Peluso
    • Jinghua Shi
    • Tiffany Liang
    • Michelle C. Stitzer
    • Bo Wang
    • Michael S. Campbell
    • Joshua C. Stein
    • Xuehong Wei
    • Chen-Shan Chin
    • Katherine Guill
    • Michael Regulski
    • Sunita Kumari
    • Andrew Olson
    • Jonathan Gent
    • Kevin L. Schneider
    • Thomas K. Wolfgruber
    • Michael R. May
    • Nathan M. Springer
    • Eric Antoniou
    • W. Richard McCombie
    • Gernot G. Presting
    • Michael McMullen
    • Jeffrey Ross-Ibarra
    • R. Kelly Dawe
    • Alex Hastie
    • David R. Rank
    • Doreen Ware

    An improved reference genome for maize, using single-molecule sequencing and high-resolution optical mapping, enables characterization of structural variation and repetitive regions, and identifies lineage expansions of transposable elements that are unique to maize.

  • 病原性細菌 : FimHアンタゴニストによる腸内の尿路病原性大腸菌の選択的除去

    • Caitlin N. Spaulding
    • Roger D. Klein
    • Sテゥgolティne Ruer
    • Andrew L. Kau
    • Henry L. Schreiber
    • Zachary T. Cusumano
    • Karen W. Dodson
    • Jerome S. Pinkner
    • Daved H. Fremont
    • James W. Janetka
    • Han Remaut
    • Jeffrey I. Gordon
    • Scott J. Hultgren

    Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.

    See also
  • 発生生物学 : 多細胞系譜間の相互作用が多能性状態からのヒト肝芽発生を調節する

    • J. Gray Camp
    • Keisuke Sekine
    • Tobias Gerber
    • Henry Loeffler-Wirth
    • Hans Binder
    • Malgorzata Gac
    • Sabina Kanton
    • Jorge Kageyama
    • Georg Damm
    • Daniel Seehofer
    • Lenka Belicova
    • Marc Bickle
    • Rico Barsacchi
    • Ryo Okuda
    • Emi Yoshizawa
    • Masaki Kimura
    • Hiroaki Ayabe
    • Hideki Taniguchi
    • Takanori Takebe
    • Barbara Treutlein

    Single-cell RNA sequencing analysis of two- and three-dimensional hepatic differentiation reveals that both systems recapitulate certain transcriptomic features of human hepatogenesis.

  • 神経炎症 : I型インターフェロンが介在するループスにおけるミクログリア依存的なシナプス消失

    • Allison R. Bialas
    • Jessy Presumey
    • Abhishek Das
    • Cees E. van der Poel
    • Peter H. Lapchak
    • Luka Mesin
    • Gabriel Victora
    • George C. Tsokos
    • Christian Mawrin
    • Ronald Herbst
    • Michael C. Carroll

    Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.

    See also
  • がん : BAP1は、ミトコンドリアへのIP3R3を介したCa 2+ 流入量を調節して細胞の形質転換を抑制する

    • Angela Bononi
    • Carlotta Giorgi
    • Simone Patergnani
    • David Larson
    • Kaitlyn Verbruggen
    • Mika Tanji
    • Laura Pellegrini
    • Valentina Signorato
    • Federica Olivetto
    • Sandra Pastorino
    • Masaki Nasu
    • Andrea Napolitano
    • Giovanni Gaudino
    • Paul Morris
    • Greg Sakamoto
    • Laura K. Ferris
    • Alberto Danese
    • Andrea Raimondi
    • Carlo Tacchetti
    • Shafi Kuchay
    • Harvey I. Pass
    • El Bachir Affar
    • Haining Yang
    • Paolo Pinton
    • Michele Carbone

    BRCA1-associated protein 1 (BAP1) regulates calcium flux in the endoplasmic reticulum to facilitate the execution of apoptosis, unveiling a new facet of the role of BAP1 as an environmental tumour suppressor.

  • がん : PTENはFBXL2に対抗してIP3R3とCa 2+ が仲介するアポトーシスを促進し、腫瘍増殖を制限する

    • Shafi Kuchay
    • Carlotta Giorgi
    • Daniele Simoneschi
    • Julia Pagan
    • Sonia Missiroli
    • Anita Saraf
    • Laurence Florens
    • Michael P. Washburn
    • Ana Collazo-Lorduy
    • Mireia Castillo-Martin
    • Carlos Cordon-Cardo
    • Said M. Sebti
    • Paolo Pinton
    • Michele Pagano

    PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.


  • Addendum: The antibody aducanumab reduces Aホイ plaques in Alzheimer窶冱 disease

    • Jeff Sevigny
    • Ping Chiao
    • Thierry Bussiティre
    • Paul H. Weinreb
    • Leslie Williams
    • Marcel Maier
    • Robert Dunstan
    • Stephen Salloway
    • Tianle Chen
    • Yan Ling
    • John O窶僭orman
    • Fang Qian
    • Mahin Arastu
    • Mingwei Li
    • Sowmya Chollate
    • Melanie S. Brennan
    • Omar Quintero-Monzon
    • Robert H. Scannevin
    • H. Moore Arnold
    • Thomas Engber
    • Kenneth Rhodes
    • James Ferrero
    • Yaming Hang
    • Alvydas Mikulskis
    • Jan Grimm
    • Christoph Hock
    • Roger M. Nitsch
    • Alfred Sandrock