Table of Contents

Volume 546 Number 7659 pp451-570

22 June 2017

About the cover

The cover shows an artist’s impression of the Jupiter-like gas giant KELT-9b (bottom) in orbit around the massive star KELT-9. In this issue, Scott Gaudi, Keivan Stassun and their colleagues report the discovery of KELT-9b and reveal it to be one of the hottest exoplanets so far identified. Its dayside surface temperature is about 4,600 K — hotter than most stars, and hot enough to vaporize its atmosphere and to dissociate any molecules into their constituent atoms. The planet is nearly three times more massive than Jupiter but only half as dense. It takes roughly 1.5 days to orbit its host star, and, because it is constantly being blasted with high levels of ultraviolet radiation, it may be shedding a tail of material much like a comet. The rate of ablation may be sufficient for KELT-9b to evaporate completely before its host star reaches the end of its life — assuming that the star doesn ’t grow and engulf the planet first. As only the seventh ‘hot Jupiter’ to be found orbiting a hot A-type star, KELT-9b should help deepen understanding of planetary systems around massive stars, the authors say. Cover image: NASA/JPL-Caltech/R. Hurt (IPAC)

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Brief Communication Arising

  • Zanos et al. reply

    • Panos Zanos
    • Ruin Moaddel
    • Patrick J. Morris
    • Polymnia Georgiou
    • Jonathan Fischell
    • Greg I. Elmer
    • Manickavasagom Alkondon
    • Peixiong Yuan
    • Heather J. Pribut
    • Nagendra S. Singh
    • Katina S. S. Dossou
    • Yuhong Fang
    • Xi-Ping Huang
    • Cheryl L. Mayo
    • Edson X. Albuquerque
    • Scott M. Thompson
    • Craig J. Thomas
    • Carlos A. Zarate
    • Todd D. Gould


  • Strong constraints on aerosol–cloud interactions from volcanic eruptions

    • Florent F. Malavelle
    • Jim M. Haywood
    • Andy Jones
    • Andrew Gettelman
    • Lieven Clarisse
    • Sophie Bauduin
    • Richard P. Allan
    • Inger Helene H. Karset
    • Jón Egill Kristjánsson
    • Lazaros Oreopoulos
    • Nayeong Cho
    • Dongmin Lee
    • Nicolas Bellouin
    • Olivier Boucher
    • Daniel P. Grosvenor
    • Ken S. Carslaw
    • Sandip Dhomse
    • Graham W. Mann
    • Anja Schmidt
    • Hugh Coe
    • Margaret E. Hartley
    • Mohit Dalvi
    • Adrian A. Hill
    • Ben T. Johnson
    • Colin E. Johnson
    • Jeff R. Knight
    • Fiona M. O’Connor
    • Daniel G. Partridge
    • Philip Stier
    • Gunnar Myhre
    • Steven Platnick
    • Graeme L. Stephens
    • Hanii Takahashi
    • Thorvaldur Thordarson

    Investigations of an Icelandic volcanic eruption confirm that sulfate aerosols caused a discernible yet transient brightening effect, as predicted, but their effect on the liquid water path was unexpectedly negligible.

    See also
  • Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

    • Sushrut Kamerkar
    • Valerie S. LeBleu
    • Hikaru Sugimoto
    • Sujuan Yang
    • Carolina F. Ruivo
    • Sonia A. Melo
    • J. Jack Lee
    • Raghu Kalluri

    Exosomes improve the delivery of siRNA to mutant KRAS in the pancreatic tumours and bypass immune clearance better than artificial liposomes, probably owing to enhanced macropinocytocis and presence of CD47 on exosomes, respectively.

  • Structure of the human multidrug transporter ABCG2

    • Nicholas M. I. Taylor
    • Ioannis Manolaridis
    • Scott M. Jackson
    • Julia Kowal
    • Henning Stahlberg
    • Kaspar P. Locher

    The structure of human ABCG2 bound to an inhibitory antibody using cryo-electron microscopy, representing the first high-resolution structural data of a human multidrug transporter.


  • A massive, dead disk galaxy in the early Universe

    • Sune Toft
    • Johannes Zabl
    • Johan Richard
    • Anna Gallazzi
    • Stefano Zibetti
    • Moire Prescott
    • Claudio Grillo
    • Allison W. S. Man
    • Nicholas Y. Lee
    • Carlos Gómez-Guijarro
    • Mikkel Stockmann
    • Georgios Magdis
    • Charles L. Steinhardt

    When the Universe was just 3 billion years old, half of the most massive galaxies had already ceased star formation, and such a galaxy has now been observed using gravitational lensing, unexpectedly turning out to be a compact, fast-spinning disk galaxy rather than a proto-bulge galaxy.

  • A giant planet undergoing extreme-ultraviolet irradiation by its hot massive-star host

    • B. Scott Gaudi
    • Keivan G. Stassun
    • Karen A. Collins
    • Thomas G. Beatty
    • George Zhou
    • David W. Latham
    • Allyson Bieryla
    • Jason D. Eastman
    • Robert J. Siverd
    • Justin R. Crepp
    • Erica J. Gonzales
    • Daniel J. Stevens
    • Lars A. Buchhave
    • Joshua Pepper
    • Marshall C. Johnson
    • Knicole D. Colon
    • Eric L. N. Jensen
    • Joseph E. Rodriguez
    • Valerio Bozza
    • Sebastiano Calchi Novati
    • Giuseppe D’Ago
    • Mary T. Dumont
    • Tyler Ellis
    • Clement Gaillard
    • Hannah Jang-Condell
    • David H. Kasper
    • Akihiko Fukui
    • Joao Gregorio
    • Ayaka Ito
    • John F. Kielkopf
    • Mark Manner
    • Kyle Matt
    • Norio Narita
    • Thomas E. Oberst
    • Phillip A. Reed
    • Gaetano Scarpetta
    • Denice C. Stephens
    • Rex R. Yeigh
    • Roberto Zambelli
    • B. J. Fulton
    • Andrew W. Howard
    • David J. James
    • Matthew Penny
    • Daniel Bayliss
    • Ivan A. Curtis
    • D. L. DePoy
    • Gilbert A. Esquerdo
    • Andrew Gould
    • Michael D. Joner
    • Rudolf B. Kuhn
    • Jonathan Labadie-Bartz
    • Michael B. Lund
    • Jennifer L. Marshall
    • Kim K. McLeod
    • Richard W. Pogge
    • Howard Relles
    • Christopher Stockdale
    • T. G. Tan
    • Mark Trueblood
    • Patricia Trueblood

    The giant planet KELT-9b has a dayside temperature of about 4,600 K, which is sufficiently high to dissociate molecules and to evaporate its atmosphere, owing to its hot stellar host.

  • Improved maize reference genome with single-molecule technologiesOpen

    • Yinping Jiao
    • Paul Peluso
    • Jinghua Shi
    • Tiffany Liang
    • Michelle C. Stitzer
    • Bo Wang
    • Michael S. Campbell
    • Joshua C. Stein
    • Xuehong Wei
    • Chen-Shan Chin
    • Katherine Guill
    • Michael Regulski
    • Sunita Kumari
    • Andrew Olson
    • Jonathan Gent
    • Kevin L. Schneider
    • Thomas K. Wolfgruber
    • Michael R. May
    • Nathan M. Springer
    • Eric Antoniou
    • W. Richard McCombie
    • Gernot G. Presting
    • Michael McMullen
    • Jeffrey Ross-Ibarra
    • R. Kelly Dawe
    • Alex Hastie
    • David R. Rank
    • Doreen Ware

    An improved reference genome for maize, using single-molecule sequencing and high-resolution optical mapping, enables characterization of structural variation and repetitive regions, and identifies lineage expansions of transposable elements that are unique to maize.

  • Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

    • Caitlin N. Spaulding
    • Roger D. Klein
    • Ségolène Ruer
    • Andrew L. Kau
    • Henry L. Schreiber
    • Zachary T. Cusumano
    • Karen W. Dodson
    • Jerome S. Pinkner
    • Daved H. Fremont
    • James W. Janetka
    • Han Remaut
    • Jeffrey I. Gordon
    • Scott J. Hultgren

    Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.

    See also
  • Multilineage communication regulates human liver bud development from pluripotency

    • J. Gray Camp
    • Keisuke Sekine
    • Tobias Gerber
    • Henry Loeffler-Wirth
    • Hans Binder
    • Malgorzata Gac
    • Sabina Kanton
    • Jorge Kageyama
    • Georg Damm
    • Daniel Seehofer
    • Lenka Belicova
    • Marc Bickle
    • Rico Barsacchi
    • Ryo Okuda
    • Emi Yoshizawa
    • Masaki Kimura
    • Hiroaki Ayabe
    • Hideki Taniguchi
    • Takanori Takebe
    • Barbara Treutlein

    Single-cell RNA sequencing analysis of two- and three-dimensional hepatic differentiation reveals that both systems recapitulate certain transcriptomic features of human hepatogenesis.

  • Microglia-dependent synapse loss in type I interferon-mediated lupus

    • Allison R. Bialas
    • Jessy Presumey
    • Abhishek Das
    • Cees E. van der Poel
    • Peter H. Lapchak
    • Luka Mesin
    • Gabriel Victora
    • George C. Tsokos
    • Christian Mawrin
    • Ronald Herbst
    • Michael C. Carroll

    Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.

    See also
  • Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

    • Matthew J. Emmett
    • Hee-Woong Lim
    • Jennifer Jager
    • Hannah J. Richter
    • Marine Adlanmerini
    • Lindsey C. Peed
    • Erika R. Briggs
    • David J. Steger
    • Tao Ma
    • Carrie A. Sims
    • Joseph A. Baur
    • Liming Pei
    • Kyoung-Jae Won
    • Patrick Seale
    • Zachary Gerhart-Hines
    • Mitchell A. Lazar

    Histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude.

  • BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

    • Angela Bononi
    • Carlotta Giorgi
    • Simone Patergnani
    • David Larson
    • Kaitlyn Verbruggen
    • Mika Tanji
    • Laura Pellegrini
    • Valentina Signorato
    • Federica Olivetto
    • Sandra Pastorino
    • Masaki Nasu
    • Andrea Napolitano
    • Giovanni Gaudino
    • Paul Morris
    • Greg Sakamoto
    • Laura K. Ferris
    • Alberto Danese
    • Andrea Raimondi
    • Carlo Tacchetti
    • Shafi Kuchay
    • Harvey I. Pass
    • El Bachir Affar
    • Haining Yang
    • Paolo Pinton
    • Michele Carbone

    BRCA1-associated protein 1 (BAP1) regulates calcium flux in the endoplasmic reticulum to facilitate the execution of apoptosis, unveiling a new facet of the role of BAP1 as an environmental tumour suppressor.

  • PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

    • Shafi Kuchay
    • Carlotta Giorgi
    • Daniele Simoneschi
    • Julia Pagan
    • Sonia Missiroli
    • Anita Saraf
    • Laurence Florens
    • Michael P. Washburn
    • Ana Collazo-Lorduy
    • Mireia Castillo-Martin
    • Carlos Cordon-Cardo
    • Said M. Sebti
    • Paolo Pinton
    • Michele Pagano

    PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.


  • Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

    • Jeff Sevigny
    • Ping Chiao
    • Thierry Bussière
    • Paul H. Weinreb
    • Leslie Williams
    • Marcel Maier
    • Robert Dunstan
    • Stephen Salloway
    • Tianle Chen
    • Yan Ling
    • John O’Gorman
    • Fang Qian
    • Mahin Arastu
    • Mingwei Li
    • Sowmya Chollate
    • Melanie S. Brennan
    • Omar Quintero-Monzon
    • Robert H. Scannevin
    • H. Moore Arnold
    • Thomas Engber
    • Kenneth Rhodes
    • James Ferrero
    • Yaming Hang
    • Alvydas Mikulskis
    • Jan Grimm
    • Christoph Hock
    • Roger M. Nitsch
    • Alfred Sandrock