Table of Contents

Volume 544 Number 7651 pp393-514

27 April 2017

About the cover

Domesticated some 10,000 years ago, barley has been a key crop since the dawn of agriculture. In this week’s issue, Nils Stein and colleagues in the International Barley Sequencing Consortium report the sequencing and assembly of a reference genome for this important grain. They produced the genome for Hordeum vulgare L. by combining hierarchical shotgun sequencing of bacterial artificial chromosomes, genome mapping on nanochannel arrays and chromosome-scale scaffolding with conformation capture sequencing. The result is the first comprehensive, completely ordered assembly of the pericentromeric regions of a Triticeae genome — and it reveals that each of barley’s seven chromosomes is divided into three compartments. The authors also sequenced and examined genetic diversity in the exomes of 96 European elite barley lines with a spring or winter growth habit, highlighting the potential utility of the sequence for cereal genomics and breeding programmes. Cover image: Gerd Ludwig/NGC

This Week

Editorials

Top

World View

Top
  • Planetariums — not just for kids

    Planetariums are not just for education, or even astronomy: they could display all sorts of data, if only scientists thought to use them, says Tom Kwasnitschka.

Research Highlights

Top

Seven Days

Top

News in Focus

Feature

Top

comment

  • Reviewers are blinkered by bibliometrics

    Science panels still rely on poor proxies to judge quality and impact. That results in risk-averse research, say Paula Stephan, Reinhilde Veugelers and Jian Wang.

Books and Arts

Top
  • Psychology: Science in spite of itself

    Barbara A. Spellman hails an analysis of reproducibility in psychology by a champion for change.

    • Review of The Seven Deadly Sins of Psychology: A Manifesto for Reforming the Culture of Scientific Practice
      Chris Chambers
  • Books in brief

    Barbara Kiser reviews five of the week's best science picks.

Correspondence

Top

Careers

Features

Top

Career Briefs

Top

naturejobs job listings and advertising features

Futures

Specials

research

Articles

Top
  • A chromosome conformation capture ordered sequence of the barley genomeOpen

    • Martin Mascher
    • Heidrun Gundlach
    • Axel Himmelbach
    • Sebastian Beier
    • Sven O. Twardziok
    • Thomas Wicker
    • Volodymyr Radchuk
    • Christoph Dockter
    • Pete E. Hedley
    • Joanne Russell
    • Micha Bayer
    • Luke Ramsay
    • Hui Liu
    • Georg Haberer
    • Xiao-Qi Zhang
    • Qisen Zhang
    • Roberto A. Barrero
    • Lin Li
    • Stefan Taudien
    • Marco Groth
    • Marius Felder
    • Alex Hastie
    • Hana Šimková
    • Helena Staňková
    • Jan Vrána
    • Saki Chan
    • María Muñoz-Amatriaín
    • Rachid Ounit
    • Steve Wanamaker
    • Daniel Bolser
    • Christian Colmsee
    • Thomas Schmutzer
    • Lala Aliyeva-Schnorr
    • Stefano Grasso
    • Jaakko Tanskanen
    • Anna Chailyan
    • Dharanya Sampath
    • Darren Heavens
    • Leah Clissold
    • Sujie Cao
    • Brett Chapman
    • Fei Dai
    • Yong Han
    • Hua Li
    • Xuan Li
    • Chongyun Lin
    • John K. McCooke
    • Cong Tan
    • Penghao Wang
    • Songbo Wang
    • Shuya Yin
    • Gaofeng Zhou
    • Jesse A. Poland
    • Matthew I. Bellgard
    • Ljudmilla Borisjuk
    • Andreas Houben
    • Jaroslav Doležel
    • Sarah Ayling
    • Stefano Lonardi
    • Paul Kersey
    • Peter Langridge
    • Gary J. Muehlbauer
    • Matthew D. Clark
    • Mario Caccamo
    • Alan H. Schulman
    • Klaus F. X. Mayer
    • Matthias Platzer
    • Timothy J. Close
    • Uwe Scholz
    • Mats Hansson
    • Guoping Zhang
    • Ilka Braumann
    • Manuel Spannagl
    • Chengdao Li
    • Robbie Waugh
    • Nils Stein

    The International Barley Genome Sequencing Consortium reports sequencing and assembly of a reference genome for barley, Hordeum vulgare.

    See also
  • Structure and allosteric inhibition of excitatory amino acid transporter 1

    • Juan C. Canul-Tec
    • Reda Assal
    • Erica Cirri
    • Pierre Legrand
    • Sébastien Brier
    • Julia Chamot-Rooke
    • Nicolas Reyes

    High-resolution structures of the thermostabilized human excitatory amino acid transporter EAAT1, alone or in association with its substrate or small molecule inhibitors, reveal architectural features of human SLC1 transporters and an allosteric mechanism of inhibition.

Letters

Top
  • A universal model for solar eruptions

    • Peter F. Wyper
    • Spiro K. Antiochos
    • C. Richard DeVore

    Simulations of a solar coronal jet driven by filament ejection demonstrate that magnetic reconnection underlies the energy release, implying that a universal ‘breakout’ model explains both tiny jets and huge mass ejections from the Sun.

  • Predicting crystal growth via a unified kinetic three-dimensional partition model

    • Michael W. Anderson
    • James T. Gebbie-Rayet
    • Adam R. Hill
    • Nani Farida
    • Martin P. Attfield
    • Pablo Cubillas
    • Vladislav A. Blatov
    • Davide M. Proserpio
    • Duncan Akporiaye
    • Bjørnar Arstad
    • Julian D. Gale

    A general simulation approach that can replicate, and in theory predict, the growth of a wide range of crystal types, including porous, molecular and ionic crystals, is demonstrated.

  • Ultrastrong steel via minimal lattice misfit and high-density nanoprecipitation

    • Suihe Jiang
    • Hui Wang
    • Yuan Wu
    • Xiongjun Liu
    • Honghong Chen
    • Mengji Yao
    • Baptiste Gault
    • Dirk Ponge
    • Dierk Raabe
    • Akihiko Hirata
    • Mingwei Chen
    • Yandong Wang
    • Zhaoping Lu

    A method of producing superstrong yet ductile steels using cheaper and lighter alloying elements is described, based on minimization of the lattice misfit to achieve a maximal dispersion of nanoprecipitates, leading to ultimate precipitation strengthening.

  • Super-multiplex vibrational imaging

    • Lu Wei
    • Zhixing Chen
    • Lixue Shi
    • Rong Long
    • Andrew V. Anzalone
    • Luyuan Zhang
    • Fanghao Hu
    • Rafael Yuste
    • Virginia W. Cornish
    • Wei Min

    Stimulated Raman scattering under electronic pre-resonance conditions, combined with a new palette of probes, enables super-multiplex imaging of molecular targets in living cells with very high vibrational selectivity and sensitivity.

    See also
  • Abrasion-set limits on Himalayan gravel flux

    • Elizabeth H. Dingle
    • Mikaël Attal
    • Hugh D. Sinclair

    The amount of coarse gravel transported out of the Himalayan mountains by rivers is insensitive to catchment size, because the majority of gravel sourced more than 100 kilometres upstream of the mountain front is abraded into sand before it reaches the Ganga Plain.

  • A 130,000-year-old archaeological site in southern California, USA

    • Steven R. Holen
    • Thomas A. Deméré
    • Daniel C. Fisher
    • Richard Fullagar
    • James B. Paces
    • George T. Jefferson
    • Jared M. Beeton
    • Richard A. Cerutti
    • Adam N. Rountrey
    • Lawrence Vescera
    • Kathleen A. Holen

    Evidence of mastodon bone modifications for marrow extraction and/or tool production, found in the presence of hammerstones and anvils that showed use-wear and impact marks, suggest the presence of Homo in North America around 130 thousand years ago.

    See also
  • The earliest bird-line archosaurs and the assembly of the dinosaur body plan

    • Sterling J. Nesbitt
    • Richard J. Butler
    • Martín D. Ezcurra
    • Paul M. Barrett
    • Michelle R. Stocker
    • Kenneth D. Angielczyk
    • Roger M. H. Smith
    • Christian A. Sidor
    • Grzegorz Niedźwiedzki
    • Andrey G. Sennikov
    • Alan J. Charig

    The archosaur species Teleocrater rhadinus, part of the new clade Aphanosauria, is an example of the earliest divergence of the avian stem lineage (Avemetatarsalia), the lineage that contains dinosaurs (including birds).

  • Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

    • Joseph M. Castellano
    • Kira I. Mosher
    • Rachelle J. Abbey
    • Alisha A. McBride
    • Michelle L. James
    • Daniela Berdnik
    • Jadon C. Shen
    • Bende Zou
    • Xinmin S. Xie
    • Martha Tingle
    • Izumi V. Hinkson
    • Martin S. Angst
    • Tony Wyss-Coray

    Treatment with plasma of an early developmental stage, human umbilical cord, revitalizes the hippocampus and improves cognitive function in aged mice.

  • SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin

    • Jun Chen
    • Ming-Chao Zhong
    • Huaijian Guo
    • Dominique Davidson
    • Sabrin Mishel
    • Yan Lu
    • Inmoo Rhee
    • Luis-Alberto Pérez-Quintero
    • Shaohua Zhang
    • Mario-Ernesto Cruz-Munoz
    • Ning Wu
    • Donald C. Vinh
    • Meenal Sinha
    • Virginie Calderon
    • Clifford A. Lowell
    • Jayne S. Danska
    • André Veillette

    The identification of homotypic SLAMF7 interactions responsible for haematopoietic tumour cell phagocytosis by macrophages when the inhibitory receptor/ligand interaction of SIRPα/CD47 is blocked therapeutically.

  • High-avidity IgA protects the intestine by enchaining growing bacteria

    • Kathrin Moor
    • Médéric Diard
    • Mikael E. Sellin
    • Boas Felmy
    • Sandra Y. Wotzka
    • Albulena Toska
    • Erik Bakkeren
    • Markus Arnoldini
    • Florence Bansept
    • Alma Dal Co
    • Tom Völler
    • Andrea Minola
    • Blanca Fernandez-Rodriguez
    • Gloria Agatic
    • Sonia Barbieri
    • Luca Piccoli
    • Costanza Casiraghi
    • Davide Corti
    • Antonio Lanzavecchia
    • Roland R. Regoes
    • Claude Loverdo
    • Roman Stocker
    • Douglas R. Brumley
    • Wolf-Dietrich Hardt
    • Emma Slack

    Oral-vaccine-induced IgA cross-links growing bacteria into clonal aggregates, inhibiting pathogenesis, adaption and the spread of antimicrobial resistance genes.

Corrigendum

Top
  • Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

    • Helge Gad
    • Tobias Koolmeister
    • Ann-Sofie Jemth
    • Saeed Eshtad
    • Sylvain A. Jacques
    • Cecilia E. Ström
    • Linda M. Svensson
    • Niklas Schultz
    • Thomas Lundbäck
    • Berglind Osk Einarsdottir
    • Aljona Saleh
    • Camilla Göktürk
    • Pawel Baranczewski
    • Richard Svensson
    • Ronnie P.-A. Berntsson
    • Robert Gustafsson
    • Kia Strömberg
    • Kumar Sanjiv
    • Marie-Caroline Jacques-Cordonnier
    • Matthieu Desroses
    • Anna-Lena Gustavsson
    • Roger Olofsson
    • Fredrik Johansson
    • Evert J. Homan
    • Olga Loseva
    • Lars Bräutigam
    • Lars Johansson
    • Andreas Höglund
    • Anna Hagenkort
    • Therese Pham
    • Mikael Altun
    • Fabienne Z. Gaugaz
    • Svante Vikingsson
    • Bastiaan Evers
    • Martin Henriksson
    • Karl S. A. Vallin
    • Olov A. Wallner
    • Lars G. J. Hammarström
    • Elisee Wiita
    • Ingrid Almlöf
    • Christina Kalderén
    • Hanna Axelsson
    • Tatjana Djureinovic
    • Jordi Carreras Puigvert
    • Maria Häggblad
    • Fredrik Jeppsson
    • Ulf Martens
    • Cecilia Lundin
    • Bo Lundgren
    • Ingrid Granelli
    • Annika Jenmalm Jensen
    • Per Artursson
    • Jonas A. Nilsson
    • Pål Stenmark
    • Martin Scobie
    • Ulrika Warpman Berglund & Thomas Helleday