Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Non-coding RNA

More uses for genomic junk

It emerges that nascent non-coding RNAs transcribed from regulatory DNA sequences called enhancers bind to the enzyme CBP to promote its activity locally. In turn, the activities of CBP stimulate further enhancer transcription.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Enhancer RNA modulates gene expression.

Notes

  1. See all news & views

References

  1. Kim, T.-K. et al. Nature 465, 182–187 (2010).

    Article  ADS  CAS  Google Scholar 

  2. Bose, D. A. et al. Cell 168, 135–149 (2017).

    Article  CAS  Google Scholar 

  3. Hendrickson, D. G., Kelley, D. R., Tenen, D., Bernstein, B. & Rinn, J. L. Genome Biol. 17, 28 (2016).

    Article  Google Scholar 

  4. Yang, Y. W. et al. eLife 3, e02046 (2014).

    Article  Google Scholar 

  5. Beltran, M. et al. Genome Res. 26, 896–907 (2016).

    Article  CAS  Google Scholar 

  6. Kaneko, S., Son, J., Bonasio, R., Shen, S. S. & Reinberg, D. Genes Dev. 28, 1983–1988 (2014).

    Article  CAS  Google Scholar 

  7. Rada-Iglesias, A. et al. Nature 470, 279–283 (2011).

    Article  ADS  CAS  Google Scholar 

  8. Thompson, P. R. et al. Nature Struct. Mol. Biol. 11, 308–315 (2004).

    Article  CAS  Google Scholar 

  9. Kaikkonen, M. U. et al. Mol. Cell 51, 310–325 (2013).

    Article  CAS  Google Scholar 

  10. Scruggs, B. S. & Adelman, K. Cold Spring Harb. Symp. Quant. Biol. 80, 33–44 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Karen Adelman.

Related links

Related links

Related links in Nature Research

Transcription: Enhancers make non-coding RNA

Gene regulation: Long RNAs wire up cancer growth

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Adelman, K., Egan, E. More uses for genomic junk. Nature 543, 183–185 (2017). https://doi.org/10.1038/543183a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/543183a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing