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Structural biology

Ion-channel mechanisms revealed

Structures of Slo1, a channel that conducts potassium ions out of cells, provide insight into the basis of its high conductance, and of its dual activation by calcium ions and increased membrane voltage. See Articles p.46 & p.52

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Figure 1: The structure of Slo1.

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References

  1. Hille, B. Ion Channels of Excitable Membranes 3rd edn (Sinauer, 2001).

    Google Scholar 

  2. Naranjo, D., Moldenhauer, H., Pincuntureo, M. & Díaz-Franulic, I. J. Gen. Physiol. 148, 277–291 (2016).

    Article  CAS  Google Scholar 

  3. Hoshi, T., Pantazis, A. & Olcese, R. Physiology (Bethesda) 28, 172–189 (2013).

    CAS  Google Scholar 

  4. Tao, X., Hite, R. K. & MacKinnon, R. Nature 541, 46–51 (2016).

    Article  ADS  Google Scholar 

  5. Hite, R. K., Tao, X. & MacKinnon, R. Nature 541, 52–57 (2016).

    Article  ADS  Google Scholar 

  6. Niu, X., Qian, X. & Magleby, K. L. Neuron 42, 745–756 (2004).

    Article  CAS  Google Scholar 

  7. Yuan, P., Leonetti, M. D., Hsiung, Y. & MacKinnon, R. Nature 481, 94–97 (2012).

    Article  ADS  CAS  Google Scholar 

  8. Xia, X.-M., Zeng, X. & Lingle, C. J. Nature 418, 880–884 (2002).

    Article  ADS  CAS  Google Scholar 

  9. Qian, X., Niu, X. & Magleby, K. L. J. Gen. Physiol. 128, 389–404 (2006).

    Article  CAS  Google Scholar 

  10. Geng, Y. & Magleby, K. L. Front. Physiol. http://dx.doi.org/10.3389/fphys.2014.00532 (2015).

  11. Yang, J. et al. Neuron 66, 871–873 (2010).

    Article  CAS  Google Scholar 

  12. Horrigan, F. T. & Aldrich, R. W. J. Gen. Physiol. 120, 267–305 (2002).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Karl L. Magleby.

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Magleby, K. Ion-channel mechanisms revealed. Nature 541, 33–34 (2017). https://doi.org/10.1038/nature21103

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