Table of Contents

Volume 538 Number 7625 pp290-420

20 October 2016

About the cover

Xenopus laevis, also known as the African clawed frog or platanna. X. laevis is an important model organism that is used in the study of vertebrate cell and developmental biology. It is a palaeotetraploid — the product of genome duplications that occurred many millions of years ago. This makes X. laevis ideal for the study of polyploidy, but has greatly complicated genome sequencing. In this issue of Nature an international research collaboration reports the X. laevis genome sequence, and compares it to that of the related X. tropicalis. Their analyses confirm that X. laevis is an allotetraploid and distinguishes two subgenomes that evolved asymmetrically — one often retained the ancestral state and the other was subject to gene loss, deletion, rearrangement and reduced expression. The two diploid progenitor species diverged about 34 million years ago, combining to form an allotetraploid about 18 million years ago. Cover photo: Paul Starosta/Getty Images

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    The two homoeologous subgenomes in the allotetraploid frog Xenopus laevis evolved asymmetrically; one often retained the ancestral state, whereas the other experienced gene loss, deletion, rearrangement and reduced gene expression.

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Addendum

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