Underactivity of the transcription factor p53 can lead to tumour development. The discovery that the SET protein binds to and inhibits p53 points to a way to unleash the tumour suppressor's activity. See Letter p.118
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References
Wasylishen, A. R. & Lozano, G. Cold Spring Harb. Perspect. Med. 6, a026211 (2016).
Wang, D. et al. Nature 538, 118–122 (2016).
The UniProt Consortium. Nucleic Acids Res. 43, D204–D212 (2015).
Lin, S.-C. & Li, Q. Cell Res. 17, 301–302 (2007).
Nair, B. C. et al. Cell Death Differ. 21, 1409–1418 (2014).
Hamard, P. J. et al. Genes Dev. 27, 1868–1885 (2013).
Simeonova, I. et al. Cell Rep. 3, 2046–2058 (2013).
Krummel, K. A., Lee, C. J., Toledo, F. & Wahl, G. M. Proc. Natl Acad. Sci. USA 102, 10188–10193 (2005).
Christensen, D. J. et al. Blood 118, 4150–4158 (2011).
Janghorban, M. et al. Proc. Natl Acad. Sci. USA 111, 9157–9162 (2014).
Olzscha, H., Sheikh, S. & La Thangue, N. B. Crit. Rev. Oncogen. 20, 1–17 (2015).
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Barton, M. Acidic shield puts a chink in p53's armour. Nature 538, 45–46 (2016). https://doi.org/10.1038/nature19469
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DOI: https://doi.org/10.1038/nature19469
