Potassium released from dying tumour cells has now been found to suppress the activity of T cells of the immune system. Enhancing the removal of potassium from T cells restores their ability to attack cancer. See Letter p.539
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The role of potassium in depth profiling of the tumor border in bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS): a pilot study
Journal of Cancer Research and Clinical Oncology Open Access 16 September 2023
-
Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective
Journal of Nanobiotechnology Open Access 19 January 2023
-
Molecular biochemical aspects of salt (sodium chloride) in inflammation and immune response with reference to hypertension and type 2 diabetes mellitus
Lipids in Health and Disease Open Access 01 August 2021
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Rosenberg, S. A. & Restifo, N. P. Science 348, 62–68 (2015).
Mahoney, K. M., Rennert, P. D. & Freeman, G. J. Nature Rev. Drug Discov. 14, 561–584 (2015).
Eil, R. et al. Nature 537, 539–543 (2016).
Richards, C. H., Mohammed, Z., Qayyum, T., Horgan, P. G. & McMillan, D. C. Future Oncol. 7, 1223–1235 (2011).
Cahalan, M. D. & Chandy, K. G. Immunol. Rev. 231, 59–87 (2009).
Klebanoff, C. A., Gattinoni, L. & Restifo, N. P. J. Immunother. 35, 651–660 (2012).
Klebanoff, C. A. et al. J. Clin. Invest. 126, 318–334 (2016).
Christophersen, P. & Wulff, H. Channels 9, 336–343 (2015).
Yip, D. et al. Clin. Cancer Res. 15, 3896–3902 (2009).
Speyer, C. L. et al. Breast Cancer Res. Treat. 157, 217–228 (2016).
Olsen, C., Tarcha, E., Probst, P., Peckham, D. & Iadonato, S. J. Invest. Dermatol. 136, B5 (2016).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
K.G.C. declares competing financial interests. See online article for details.
Related links
Rights and permissions
About this article
Cite this article
Chandy, K., Norton, R. Channelling potassium to fight cancer. Nature 537, 497–499 (2016). https://doi.org/10.1038/nature19467
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature19467
This article is cited by
-
Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective
Journal of Nanobiotechnology (2023)
-
The role of potassium in depth profiling of the tumor border in bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS): a pilot study
Journal of Cancer Research and Clinical Oncology (2023)
-
Molecular biochemical aspects of salt (sodium chloride) in inflammation and immune response with reference to hypertension and type 2 diabetes mellitus
Lipids in Health and Disease (2021)
-
Amplifying STING activation by cyclic dinucleotide–manganese particles for local and systemic cancer metalloimmunotherapy
Nature Nanotechnology (2021)
-
Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations
Gastric Cancer (2019)
