To migrate into the lungs, cancer cells in the bloodstream must cross the lung's endothelial-cell barrier. A study shows that cancer cells can achieve this feat by signalling to induce endothelial-cell death. See Letter p.215
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Alarcón, C., Tavazoie, S. Endothelial-cell killing promotes metastasis. Nature 536, 154–155 (2016). https://doi.org/10.1038/nature19465
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DOI: https://doi.org/10.1038/nature19465
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