Table of Contents

Volume 535 Number 7611 pp22-318

14 July 2016

About the cover

The cover illustrates parallel self-assembly of three ribbons from a single-layer host graphene sheet. More than twenty years ago it was envisioned that graphene could be folded and cut into useful forms as a kind of nanoscale origami. In this issue James Annett and Graham Cross describe a system in which single-layer graphene can reorganize itself into three dimensions by a process of folding, sliding and tearing. When a small flap of graphene sheet is folded over to touch itself, it spontaneously starts to slide, tearing into a ribbon-like strip in the process. On removal of a kinetic barrier, the two-dimensional material can coalesce into its more familiar three-dimensional, layered form. The driver for this peeling phenomenon is a thermodynamic mechanism that is robust enough to work over large areas even in air at room temperature. The findings hold promise as a novel mechanism to mechanically actuate two-dimensional materials as well as a new way of assembling them into complex three-dimensional architectures. Cover: Domhnall Malone

This Week

Editorials

Top

World View

Top

Seven Days

Top
  • The week in science: 8–14 July 2016

    Dwarf planet discovered beyond Neptune; unprecedented mangrove deaths linked to climate change; and French scientists protest against pick for top agriculture post.

News in Focus

News

Top

Features

Top

comment

Summer Books

Top
  • Summer books

    As labs and lecture halls empty, go out of this world with our regular reviewers' recommendations for stellar holiday reading.

Obituary

Top

Careers

Features

Top

Career Briefs

Top

naturejobs job listings and advertising features

Futures

Specials

Outlook: Pain

research

Brief Communication Arising

Top

Articles

Top
  • Phenological sensitivity to climate across taxa and trophic levels

    • Stephen J. Thackeray
    • Peter A. Henrys
    • Deborah Hemming
    • James R. Bell
    • Marc S. Botham
    • Sarah Burthe
    • Pierre Helaouet
    • David G. Johns
    • Ian D. Jones
    • David I. Leech
    • Eleanor B. Mackay
    • Dario Massimino
    • Sian Atkinson
    • Philip J. Bacon
    • Tom M. Brereton
    • Laurence Carvalho
    • Tim H. Clutton-Brock
    • Callan Duck
    • Martin Edwards
    • J. Malcolm Elliott
    • Stephen J. G. Hall
    • Richard Harrington
    • James W. Pearce-Higgins
    • Toke T. Høye
    • Loeske E. B. Kruuk
    • Josephine M. Pemberton
    • Tim H. Sparks
    • Paul M. Thompson
    • Ian White
    • Ian J. Winfield
    • Sarah Wanless

    An ambitious study has used more than 10,000 datasets to examine how the phenological characteristics—such as the timing of reproduction—of various taxa alter in response to climate change, and suggests that differing levels of climate sensitivity could lead to the desynchronization of seasonal events over time.

    See also
  • Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma

    • John T. Powers
    • Kaloyan M. Tsanov
    • Daniel S. Pearson
    • Frederik Roels
    • Catherine S. Spina
    • Richard Ebright
    • Marc Seligson
    • Yvanka de Soysa
    • Patrick Cahan
    • Jessica Theißen
    • Ho-Chou Tu
    • Areum Han
    • Kyle C. Kurek
    • Grace S. LaPier
    • Jihan K. Osborne
    • Samantha J. Ross
    • Marcella Cesana
    • James J. Collins
    • Frank Berthold
    • George Q. Daley

    Disparate modes of suppression of the let-7 microRNA family are selectively and inversely related in neuroblastoma.

  • A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

    • Mary E. Matyskiela
    • Gang Lu
    • Takumi Ito
    • Barbra Pagarigan
    • Chin-Chun Lu
    • Karen Miller
    • Wei Fang
    • Nai-Yu Wang
    • Derek Nguyen
    • Jack Houston
    • Gilles Carmel
    • Tam Tran
    • Mariko Riley
    • Lyn’Al Nosaka
    • Gabriel C. Lander
    • Svetlana Gaidarova
    • Shuichan Xu
    • Alexander L. Ruchelman
    • Hiroshi Handa
    • James Carmichael
    • Thomas O. Daniel
    • Brian E. Cathers
    • Antonia Lopez-Girona
    • Philip P. Chamberlain

    This paper reports the identification of a new cereblon-modulating agent, CC-885, which targets the translation termination factor GSPT1 and demonstrates anti-tumour activity in patient-derived tumour cells; the crystal structure of the cereblon–DDB1–GSPT1–CC-885 complex reveals a common motif for cereblon-substrate recruitment.

Letters

Top
  • Imaging the water snow-line during a protostellar outburst

    • Lucas A. Cieza
    • Simon Casassus
    • John Tobin
    • Steven P. Bos
    • Jonathan P. Williams
    • Sebastian Perez
    • Zhaohuan Zhu
    • Claudio Caceres
    • Hector Canovas
    • Michael M. Dunham
    • Antonio Hales
    • Jose L. Prieto
    • David A. Principe
    • Matthias R. Schreiber
    • Dary Ruiz-Rodriguez
    • Alice Zurlo

    The snow-line is the distance from a protostar at which a particular volatile gas condenses; images of the protostar V883 Ori suggest that the water snow-line migrated outwards during a protostellar outburst, with implications for our understanding of the formation of planetary systems such as our own.

    See also
  • A sensitive electrometer based on a Rydberg atom in a Schrödinger-cat state

    • Adrien Facon
    • Eva-Katharina Dietsche
    • Dorian Grosso
    • Serge Haroche
    • Jean-Michel Raimond
    • Michel Brune
    • Sébastien Gleyzes

    A highly sensitive electrometer is reported that is based on a Schrödinger-cat state in a Rydberg atom, that reaches a sensitivity beyond the standard quantum limit and can compete with state-of-the-art electric field measurements performed using electromechanical resonators and single-electron transistors.

    See also
  • Transport evidence for Fermi-arc-mediated chirality transfer in the Dirac semimetal Cd3As2

    • Philip J. W. Moll
    • Nityan L. Nair
    • Toni Helm
    • Andrew C. Potter
    • Itamar Kimchi
    • Ashvin Vishwanath
    • James G. Analytis

    Electronic transport measurements in a magnetic field on the topological Dirac semimetal Cd3As2 identify the predicted Weyl orbits that weave Fermi arcs and bulk states together; the Weyl orbits enable transfer of chirality from one node to another, and open up the possibility of controlling topological properties electronically.

  • Mid-ocean-ridge seismicity reveals extreme types of ocean lithosphere

    • Vera Schlindwein
    • Florian Schmid

    The structure and accretion modes of two end-member types of oceanic lithosphere are described using a detailed seismicity survey along 390 kilometres of an ultraslow ridge axis, indicating deeper seismicity in amagmatic regions and explaining the uneven crustal production at ultraslow-spreading ridges.

  • Molecular logic behind the three-way stochastic choices that expand butterfly colour vision

    • Michael Perry
    • Michiyo Kinoshita
    • Giuseppe Saldi
    • Lucy Huo
    • Kentaro Arikawa
    • Claude Desplan

    Butterflies diversify their retinal mosaics by producing three stochastic types of ommatidia instead of the two types found in Drosophila; this study shows that butterfly retinas use two R7-like photoreceptors per ommatidium that each make an independent stochastic decision to express the transcription factor Spineless, which controls photoreceptor and ommatidial fate.

  • Dissociated functional significance of decision-related activity in the primate dorsal stream

    • Leor N. Katz
    • Jacob L. Yates
    • Jonathan W. Pillow
    • Alexander C. Huk

    Activity in regions of the brain have been correlated with decision making but determining whether such relationships are correlative or causative has been challenging; using a technique to reversibly inactivate brain areas in monkeys reveals that although there is decision-related activity in the lateral intraparietal (LIP) area, LIP is not critical for the perceptual decisions studied here.

  • Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification

    • Sven Reischauer
    • Oliver A. Stone
    • Alethia Villasenor
    • Neil Chi
    • Suk-Won Jin
    • Marcel Martin
    • Miler T. Lee
    • Nana Fukuda
    • Michele Marass
    • Alec Witty
    • Ian Fiddes
    • Taiyi Kuo
    • Won-Suk Chung
    • Sherveen Salek
    • Robert Lerrigo
    • Jessica Alsiö
    • Shujun Luo
    • Dominika Tworus
    • Sruthy M. Augustine
    • Sophie Mucenieks
    • Björn Nystedt
    • Antonio J. Giraldez
    • Gary P. Schroth
    • Olov Andersson
    • Didier Y. R. Stainier

    The zebrafish cloche gene is required for the formation of most endothelial and haematopoietic cells, however, it has been difficult to isolate; this study reveals that cloche encodes a PAS-domain-containing bHLH transcription factor, and a mammalian orthologue can partially rescue cloche mutants, indicating a possible conserved role in mammals.

  • Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

    • Philipp S. Hoppe
    • Michael Schwarzfischer
    • Dirk Loeffler
    • Konstantinos D. Kokkaliaris
    • Oliver Hilsenbeck
    • Nadine Moritz
    • Max Endele
    • Adam Filipczyk
    • Adriana Gambardella
    • Nouraiz Ahmed
    • Martin Etzrodt
    • Daniel L. Coutu
    • Michael A. Rieger
    • Carsten Marr
    • Michael K. Strasser
    • Bernhard Schauberger
    • Ingo Burtscher
    • Olga Ermakova
    • Antje Bürger
    • Heiko Lickert
    • Claus Nerlov
    • Fabian J. Theis
    • Timm Schroeder

    Live imaging and single-cell analyses are used to show that decision-making by differentiating haematopoietic stem cells between the megakaryocytic–erythroid and granulocytic–monocytic lineages is not initiated by stochastic switching between the lineage-specific transcription factors PU.1 and GATA1, which challenges the previous model of early myeloid lineage choice.

  • TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis

    • Joanne Hsieh
    • Masahiro Koseki
    • Matthew M. Molusky
    • Emi Yakushiji
    • Ikuyo Ichi
    • Marit Westerterp
    • Jahangir Iqbal
    • Robin B. Chan
    • Sandra Abramowicz
    • Liana Tascau
    • Shunichi Takiguchi
    • Shizuya Yamashita
    • Carrie L. Welch
    • Gilbert Di Paolo
    • M. Mahmood Hussain
    • Jay H. Lefkowitch
    • Daniel J. Rader
    • Alan R. Tall

    In mice, deficiency in the high-density lipoprotein gene T39 stabilizes liver X receptor (LXR), reducing both atherosclerosis and steatohepatitis, suggesting that T39 inhibition could be an effective strategy for reducing these diseases.