A protein in the pathogenic bacterium Legionella pneumophila has been found to attach the modifying molecule ubiquitin to human proteins, using a mechanism that, surprisingly, does not involve cellular E1 and E2 enzymes. See Letter p.120
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions
Journal of Hematology & Oncology Open Access 31 July 2023
-
The role of ubiquitination in tumorigenesis and targeted drug discovery
Signal Transduction and Targeted Therapy Open Access 29 February 2020
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Hershko, A., Ciechanover, A. & Varshavsky, A. Nature Med. 6, 1073–1081 (2000).
Qiu, J. et al. Nature 533, 120–124 (2016).
Schulman, B. A. & Harper, J. W. Nature Rev. Mol. Cell Biol. 10, 319–331 (2009).
Joazeiro, C. A. P. & Hunter, T. Science 289, 2061–2062 (2000).
Maculins, T., Fiskin, E., Bhogaraju, S. & Dikic, I. Cell Res. 26, 499–510 (2016).
Hubber, A. & Roy, C. R. Annu. Rev. Cell Dev. Biol. 26, 261–283 (2010).
Xu, L. & Luo, Z.-Q. Microbes Infect. 15, 157–167 (2013).
Bardill, J. P., Miller, J. L. & Vogel, J. P. Mol. Microbiol. 56, 90–103 (2005).
Barkauskaite, E., Jankevicius, G. & Ahel, I. Mol. Cell 58, 935–946 (2015).
Haas, A. L. & Rose, I. A. J. Biol. Chem. 257, 10329–10337 (1982).
Glowacki, G. et al. Protein Sci. 11, 1657–1670 (2002).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Bhogaraju, S., Dikic, I. Ubiquitination without E1 and E2 enzymes. Nature 533, 43–44 (2016). https://doi.org/10.1038/nature17888
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature17888
This article is cited by
-
Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions
Journal of Hematology & Oncology (2023)
-
Electron transfer in protein modifications: from detection to imaging
Science China Chemistry (2023)
-
The role of ubiquitination in tumorigenesis and targeted drug discovery
Signal Transduction and Targeted Therapy (2020)
-
Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders
Journal of Biosciences (2020)
-
Exploring the Structural Mechanism of Covalently Bound E3 Ubiquitin Ligase: Catalytic or Allosteric Inhibition?
The Protein Journal (2018)