A high-throughput approach has found clusters of DNA double-strand breaks in neural cells. Most of the clusters are in large genes that are associated with neural function, which suggests that the breaks may have tissue-specific roles.
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Glover, T., Wilson, T. Breaks in the brain. Nature 532, 46–47 (2016). https://doi.org/10.1038/nature17316
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DOI: https://doi.org/10.1038/nature17316
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Transcription-associated DNA DSBs activate p53 during hiPSC-based neurogenesis
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