Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Organ-seeking vesicles

An analysis reveals that cancer cells remotely prepare distant sites for tumour spread in an organ-specific manner, by deploying organ-seeking extracellular vesicles. See Article p.329

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Paving the way for organ-specific metastasis.

Notes

  1. See all news & views

References

  1. Paget, S. Lancet 1, 571–573 (1889).

    Article  Google Scholar 

  2. Fidler, I. J. Nature Rev. Cancer 3, 453–458 (2003).

    Article  ADS  CAS  Google Scholar 

  3. Nguyen, D. X., Bos, P. D. & Massagué, J. Nature Rev. Cancer 9, 274–284 (2009).

    Article  CAS  Google Scholar 

  4. Hoshino, A. et al. Nature 527, 329–335 (2015).

    Article  ADS  CAS  Google Scholar 

  5. Peinado, H. et al. Nature Med. 18, 883–891 (2012).

    Article  CAS  Google Scholar 

  6. Lötvall, J. et al. J. Extracell. Vesicles 3, 26913 (2014).

    Article  Google Scholar 

  7. Colombo, M., Raposo, G. & Théry, C. Annu. Rev. Cell Dev. Biol. 30, 255–289 (2014).

    Article  CAS  Google Scholar 

  8. Rak, J. Front. Pharmacol. 4, 21 (2013).

    Article  Google Scholar 

  9. Hood, J. L., San, R. S. & Wickline, S. A. Cancer Res. 71, 3792–3801 (2011).

    Article  CAS  Google Scholar 

  10. Poste, G. & Nicolson, G. L. Proc. Natl Acad. Sci. USA 77, 399–403 (1980).

    Article  ADS  CAS  Google Scholar 

  11. Kaplan, R. N. et al. Nature 438, 820–827 (2005).

    Article  ADS  CAS  Google Scholar 

  12. Costa-Silva, B. et al. Nature Cell Biol. 17, 816–826 (2015).

    Article  CAS  Google Scholar 

  13. Steeg, P. S., Camphausen, K. A. & Smith, Q. R. Nature Rev. Cancer 11, 352–363 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Janusz Rak.

Related audio

Related links

Related links

Related links in Nature Research

Cancer: Diagnosis by extracellular vesicles

Cancer: The complex seeds of metastasis

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rak, J. Organ-seeking vesicles. Nature 527, 312–314 (2015). https://doi.org/10.1038/nature15642

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature15642

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer