Table of Contents

Volume 527 Number 7577 pp133-268

12 November 2015

About the cover

A hollow log hive in the Cévennes mountains, France, showing circular honeycomb architecture characteristic of the honeybee Apis mellifera. Bees and humans have enjoyed a long association, as evidenced by bee iconography in rock art and ancient Egyptian paintings and carvings, and a few isolated reports of beeswax in archeological contexts. But when did this association become common? Mélanie Roffet-Salque et al. use the telltale gas chromatographic signature of beeswax from lipid residues preserved in pottery vessels to plot the use of beeswax across Neolithic Europe, the Middle East and North Africa. They demonstrate its extensive and possibly continuous use in some places for 8,000 years or more. The association, therefore, goes back to the beginnings of agriculture and possibly earlier. Cover photo: Eric Tourneret (http://thebeephotographer.photoshelter.com)

This Week

Editorials

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  • Universities’ value

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  • Radio interference

    Conflict at the Arecibo Observatory highlights the need for funders to become more flexible.

World View

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Seven Days

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    News in Focus

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    comment

    • Biological research: Rethink biosafety

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    Books and Arts

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    • Cancer therapy: Up close and personalized

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      • Review of The Death of Cancer
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      • Review of The Astronomer and the Witch: Johannes Kepler's Fight for his Mother
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    Correspondence

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    Careers

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    Q&As

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    naturejobs job listings and advertising features

    Futures

    research

    Articles

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    Letters

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    • A rocky planet transiting a nearby low-mass star

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      A low-mass star that is just 12 parsecs away from Earth is shown to be transited by an Earth-sized planet, GJ 1132b, which probably has a rock/iron composition and might support a substantial atmosphere.

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      Spin-entangled states between two neutral atoms in different optical tweezers are prepared by combining them in the same optical tweezer and allowing for controlled interactions, after which the particles are dynamically separated in space and their entanglement is maintained.

    • Large anomalous Hall effect in a non-collinear antiferromagnet at room temperature

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    • Liquids with permanent porosity

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      See also
    • Widespread exploitation of the honeybee by early Neolithic farmers

      • Mélanie Roffet-Salque
      • Martine Regert
      • Richard P. Evershed
      • Alan K. Outram
      • Lucy J. E. Cramp
      • Orestes Decavallas
      • Julie Dunne
      • Pascale Gerbault
      • Simona Mileto
      • Sigrid Mirabaud
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      • Jessica Smyth
      • Lucija Šoberl
      • Helen L. Whelton
      • Alfonso Alday-Ruiz
      • Henrik Asplund
      • Marta Bartkowiak
      • Eva Bayer-Niemeier
      • Lotfi Belhouchet
      • Federico Bernardini
      • Mihael Budja
      • Gabriel Cooney
      • Miriam Cubas
      • Ed M. Danaher
      • Mariana Diniz
      • László Domboróczki
      • Cristina Fabbri
      • Jesus E. González-Urquijo
      • Jean Guilaine
      • Slimane Hachi
      • Barrie N. Hartwell
      • Daniela Hofmann
      • Isabel Hohle
      • Juan J. Ibáñez
      • Necmi Karul
      • Farid Kherbouche
      • Jacinta Kiely
      • Kostas Kotsakis
      • Friedrich Lueth
      • James P. Mallory
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      • Brigitte Maurice-Chabard
      • Martin A. Mc Gonigle
      • Simone Mulazzani
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      • Fintan Walsh
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      • Lydia Zapata-Peña
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      Salamanders are the only tetrapod that can fully regenerate their limbs and tail, a capacity that might be linked to their unique preaxial mode of limb development; here, data from fossils reveal the existence of preaxial polarity in various amphibians from the Carboniferous and Permian periods, suggesting that salamander-like regeneration is an ancient feature of tetrapods that was subsequently lost at least once in the lineage leading to amniotes.

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    • Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

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      Treating ovarian cancer in mouse models with inhibitors for the epigenetic regulators EZH2 and DNMT1 increases the expression of the inflammatory chemokines CXCL9 and CXCL10, resulting in enhanced tumour infiltration by effector T cells, and slowed tumour progression.

    • The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions

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      Crystal structures of the DNA glycosylase AlkD with DNA containing various modified bases show that neither substrate recognition nor catalysis use a base-flipping mechanism; instead, AlkD scans the phosphodeoxyribose backbone for increased cationic charge imparted by the alkylated base, and then uses the positive charge to facilitate cleavage of the glycosidic bond, thus explaining the specificity of AlkD for cationic lesions.

      See also
    • Structure of a eukaryotic SWEET transporter in a homotrimeric complex

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      • Kay Perry
      • Wolf B. Frommer
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      The X-ray crystal structure is presented of a seven-transmembrane eukaryotic SWEET glucose transporter, revealing the link between seven-transmembrane eukaryotic SWEETs and their three-transmembrane bacterial homologues and providing insight into eukaryotic sugar transport mechanisms.

    Corrigenda

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    Erratum

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