The HIV protein Nef is a viral 'Swiss army knife' with many functions. New work now shows how Nef increases infectivity — by inhibiting two of the host cell's antiviral proteins, SERINC3 and SERINC5. See Articles p.212 & p.218
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References
Rosa, A. et al. Nature 526, 212–217 (2015).
Usami, Y., Wu, Y. & Göttlinger, H. G. Nature 526, 218–223 (2015).
Day, J. R., Münk, C. & Guatelli, J. C. J. Virol. 78, 1069–1079 (2004).
Aiken, C. J. Virol. 71, 5871–5877 (1997).
Chazal, N., Singer, G., Aiken, C., Hammarskjöld, M.-L. & Rekosh, D. J. Virol. 75, 4014–4018 (2001).
Zhou, J. & Aiken, C. J. Virol. 75, 5851–5859 (2001).
Pizzato, M. et al. Proc. Natl Acad. Sci. USA 104, 6812–6817 (2007).
Pizzato, M. Proc. Natl Acad. Sci. USA 107, 9364–9369 (2010).
Usami, Y. & Göttlinger, H. Cell Rep. 5, 802–812 (2013).
Inuzuka, M., Hayakawa, M. & Ingi, T. J. Biol. Chem. 280, 35776–35783 (2005).
Qi, M. & Aiken, C. J. Virol. 81, 1534–1536 (2007).
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Aiken, C. Antiviral action countered by Nef. Nature 526, 202–203 (2015). https://doi.org/10.1038/nature15637
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DOI: https://doi.org/10.1038/nature15637
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