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Regenerative biology

Maintaining liver mass

Nature volume 524, pages 165–166 (2015)Cite this article

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A previously under-appreciated subset of liver cells has been found to contribute to the day-to-day maintenance of liver mass in mice. The cells are induced and supported by signals from an adjacent vein. See Article p.180

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Figure 1: A contributor to everyday liver regeneration.

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References

  1. Miyajima, A., Tanaka, M. & Itoh, T. Cell Stem Cell 14, 561–574 (2014).

    Article  CAS  Google Scholar 

  2. Wang, B., Zhao, L., Fish, M., Logan, C. Y. & Nusse, R. Nature 524, 180–185 (2015).

    Article  CAS  ADS  Google Scholar 

  3. Malato, Y. J. Clin. Invest. 121, 4850–4860 (2011).

    Article  CAS  Google Scholar 

  4. Tarlow, B. D. et al. Cell Stem Cell 15, 605–618 (2014).

    Article  CAS  Google Scholar 

  5. Yanger, K. et al. Cell Stem Cell 15, 340–349 (2014).

    Article  CAS  Google Scholar 

  6. Magami, Y. et al. Liver 22, 419–425 (2002).

    Article  Google Scholar 

  7. Benhamouche, S. et al. Dev. Cell 10, 759–770 (2006).

    Article  CAS  Google Scholar 

  8. Yang, J. et al. Hepatology 60, 964–976 (2014).

    Article  CAS  Google Scholar 

  9. Rompolas, P., Mesa, K. R. & Greco, V. Nature 502, 513–518 (2013).

    Article  CAS  ADS  Google Scholar 

  10. Sheng, X. R., Brawley, C. M. & Matunis, E. L. Cell Stem Cell 5, 191–203 (2009).

    Article  CAS  Google Scholar 

  11. Duncan, A. W. et al. Nature 467, 707–710 (2010).

    Article  CAS  ADS  Google Scholar 

  12. Huch, M. et al. Nature 494, 247–250 (2013).

    Article  CAS  ADS  Google Scholar 

  13. Suzuki, A., Sekiya, S., Büscher, D., Izpisúa Belmonte, J. C. & Taniguchi, H. Development 135, 1589–1595 (2008).

    Article  CAS  Google Scholar 

  14. Matsumoto, K., Yoshitomi, H., Rossant, J. & Zaret, K. S. Science 294, 559–563 (2001).

    Article  CAS  ADS  Google Scholar 

Download references

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  1. Kenneth S. Zaret is at the Institute for Regenerative Medicine and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.,

    Kenneth S. Zaret

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  1. Kenneth S. Zaret
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Correspondence to Kenneth S. Zaret.

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Zaret, K. Maintaining liver mass. Nature 524, 165–166 (2015). https://doi.org/10.1038/nature15201

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