Extensive chromosomal rearrangement – chromothripsis – is seen in several cancers. Imaging and sequencing of single cells shows that this phenomenon can occur inside cellular anomalies known as micronuclei. See Article p.179
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Knouse, K., Amon, A. The micronucleus gets its big break. Nature 522, 162–163 (2015). https://doi.org/10.1038/nature14528
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DOI: https://doi.org/10.1038/nature14528
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