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Cell biology

The micronucleus gets its big break

Extensive chromosomal rearrangement – chromothripsis – is seen in several cancers. Imaging and sequencing of single cells shows that this phenomenon can occur inside cellular anomalies known as micronuclei. See Article p.179

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Figure 1: Following the fate of a micronucleus.

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References

  1. Stephens, P. J. et al. Cell 144, 27–40 (2011).

    Article  MathSciNet  CAS  Google Scholar 

  2. Zack, T. I. et al. Nature Genet. 45, 1134–1140 (2013).

    Article  CAS  Google Scholar 

  3. Zhang, C.-Z. et al. Nature 522, 179–184 (2015).

    Article  ADS  CAS  Google Scholar 

  4. Hatch, E. M., Fischer, A. H., Deerinck, T. J. & Hetzer, M. W. Cell 154, 47–60 (2013).

    Article  CAS  Google Scholar 

  5. Crasta, K. et al. Nature 482, 53–58 (2012).

    Article  ADS  CAS  Google Scholar 

  6. Janssen, A., van der Burg, M., Szuhai, K., Kops, G. J. P. L. & Medema, R. H. Science 333, 1895–1898 (2011).

    Article  ADS  CAS  Google Scholar 

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Correspondence to Angelika Amon.

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Knouse, K., Amon, A. The micronucleus gets its big break. Nature 522, 162–163 (2015). https://doi.org/10.1038/nature14528

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