Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stem cells

Asymmetric rejuvenation

Nature volume 521, pages 296–298 (2015)Cite this article

Subjects

Organelles called mitochondria are asymmetrically apportioned to the daughters of dividing stem cells according to mitochondrial age. This finding sheds light on the mechanisms underlying asymmetric stem-cell division.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Unequal sharing between daughters.

Notes

  1. See all news & views

References

  1. Katajisto, P. et al. Science 348, 340–343 (2015).

    Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

  2. Mukherjee, S., Kong, J. & Brat, D. J. Stem Cells Dev. 24, 405–416 (2015).

    Article  PubMed  Google Scholar 

  3. Nunnari, J. & Suomalainen, A. Cell 148, 1145–1159 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ito, K. & Suda, T. Nature Rev. Mol. Cell Biol. 15, 243–256 (2014).

    Article  CAS  Google Scholar 

  5. Ahlqvist, K. J. et al. Cell Metab. 15, 100–109 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. Trifunovic, A. et al. Nature 429, 417–423 (2004).

    Article  CAS  ADS  PubMed  Google Scholar 

  7. Kujoth, G. C. et al. Science 309, 481–484 (2005).

    Article  CAS  ADS  PubMed  Google Scholar 

  8. Aguilaniu, H., Gustafsson, L., Rigoulet, M. & Nyström, T. Science 299, 1751–1753 (2003).

    Article  CAS  ADS  PubMed  Google Scholar 

  9. McFaline-Figueroa, J. R. et al. Aging Cell 10, 885–895 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kirkwood, T. B. L. Nature 270, 301–304 (1977).

    Article  CAS  ADS  PubMed  Google Scholar 

  11. Ahlqvist, K. J. et al. Nature Commun. 6, 6494 (2015).

    Article  CAS  ADS  Google Scholar 

  12. Narendra, D., Tanaka, A., Suen, D.-F. & Youle, R. J. J. Cell Biol. 183, 795–803 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Anu Suomalainen is in the Research Programs Unit, Molecular Neurology, Biomedicum-Helsinki, University of Helsinki, Helsinki 00290, Finland.,

    Anu Suomalainen

Authors
  1. Anu Suomalainen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anu Suomalainen.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Suomalainen, A. Asymmetric rejuvenation. Nature 521, 296–298 (2015). https://doi.org/10.1038/521296a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/521296a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing