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Molecular biology

Rap and chirp about X inactivation

Two new techniques identify proteins that directly interact with a non-protein-coding RNA called Xist to mediate inactivation of one X chromosome in female mammals. See Letter p.232

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Figure 1: Capturing RNA–protein complexes.

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References

  1. Wutz, A. Nature Rev. Genet. 12, 542–553 (2011).

    Article  CAS  PubMed  Google Scholar 

  2. Sarma, K. et al. Cell 159, 869–883 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. McHugh, C. A. et al. Nature 521, 232–236 (2015).

    Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

  4. Chu, C. et al. Cell 161, 404–416 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lyon, M. F. Nature 190, 372–373 (1961).

    Article  CAS  ADS  PubMed  Google Scholar 

  6. Brown, C. J. et al. Nature 349, 38–44 (1991).

    Article  CAS  ADS  PubMed  Google Scholar 

  7. Zhao, J., Sun, B. K., Erwin, J. A., Song, J.-J. & Lee, J. T. Science 322, 750–756 (2008).

    Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

  8. Simon, M. D. et al. Nature 504, 465–469 (2013).

    Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

  9. Wutz, A., Rasmussen, T. P. & Jaenisch, R. Nature Genet. 30, 167–174 (2002).

    Article  CAS  PubMed  Google Scholar 

  10. Shi, Y. et al. Genes Dev. 15, 1140–1151 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. You, S.-H. et al. Nature Struct. Mol. Biol. 20, 182–187 (2013).

    Article  CAS  Google Scholar 

  12. Gutschner, T. et al. Cancer Res. 73, 1180–1189 (2013).

    Article  CAS  PubMed  Google Scholar 

  13. Gutschner, T. & Diederichs, S. RNA Biol. 9, 703–719 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Sven Diederichs.

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Roth, A., Diederichs, S. Rap and chirp about X inactivation. Nature 521, 170–171 (2015). https://doi.org/10.1038/521170a

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