Table of Contents

Volume 520 Number 7549 pp585-716

30 April 2015

About the cover

The amygdala is part of the brain important for emotional processing, handling stimuli that have either positive or negative associations — the good and the bad. Little is known about how amygdala neurons differentiate or compartmentalize these distinctions. Here, Kay Tye and colleagues identify the basolateral amygdala (BLA) as a site of divergence for circuits mediating positive and negative emotional or motivational responses. In studies in mice they find that neurons in the BLA projecting to fear or reward circuits undergo opposing changes in synaptic strength following fear or reward conditioning. Selective activation of neural populations causes, respectively, either negative or positive reinforcement. Transcriptome analysis reveals candidate genes that may mediate these functional differences. Cover art: Insil Choi.

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World View


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  • Seven days: 24–30 April 2015

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    News in Focus




    Books and Arts

    • Climate economics: The high road

      Michael Grubb is both swept away and frustrated by Nicholas Stern's argument for tackling climate change.

      • Review of Why Are We Waiting?: The Logic, Urgency, and Promise of Tackling Climate Change
        Nicholas Stern
    • Genetics: We are the 98%

      Nathaniel Comfort unpicks the metaphors in a trio of books exploring the 'junk'-ridden genome.

      • Review of Biocode: The New Age of Genomics, The Deeper Genome: Why There Is More to the Human Genome Than Meets the Eye and Junk DNA: A Journey Through the Dark Matter of the Genome
        Dawn Field, Neil Davies, John Parrington & Nessa Carey
    • New in paperback

      • Review of Neanderthal Man: In Search of Lost Genomes, The Homing Instinct: Meaning and Mystery in Animal Migration, The Accidental Species: Misunderstandings of Human Evolution, This Changes Everything: Capitalism vs the Climate, The Boom: How Fracking Ignited the American Energy Revolution and Changed the World, The Knowledge: How to Rebuild Our World After an Apocalypse, Islands Beyond the Horizon: The Life of Twenty of the World's Most Remote Places, Water 4.0, The Tale of the Duelling Neurosurgeons, Tesla: Inventor of the Electrical Age, Infinitesimal: How a Dangerous Mathematical Theory Shaped the Modern World, A Rough Ride to the Future and Junkyard Planet: Travels in the Billion-Dollar Trash Trade
        Svante Pääbo, Bernd Heinrich, Henry Gee, Naomi Klein, Russell Gold, Lewis Dartnell, Roger Lovegrove, David Sedlak, Sam Kean, W. Bernard Carlson, Amir Alexander, James Lovelock & Adam Minter
    • Origins of life: An improbable journey

      Adrian Woolfson enjoys two studies on microbial life's trek towards complexity.

      • Review of The Vital Question: Why is Life the Way it is? and Life's Engines: How Microbes Made Earth Habitable
        Nick Lane & Paul G. Falkowski
    • Virology: Journal of the plague years

      Mark Dybul applauds the latest chapter in an account of a life at the leading edge of HIV research and policy.

      • Review of AIDS Between Science and Politics
        Peter Piot
    • Physics: One hundred years of general relativity

      Pedro Ferreira looks back at how Einstein himself and a panoply of other physicists have framed the theory.

      • Review of Relativity: The Special and the General Theory (100th Anniversary edition) and The Road to Relativity: The History and Meaning of Einstein's “The Foundation of General Relativity” Featuring the Original Manuscript of Einstein's Masterpiece
        Albert Einstein, Hanoch Gutfreund & Jürgen Renn








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      • Jonathan E. Grindlay
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    • An epigenome-wide association study of total serum immunoglobulin E concentration

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    • TP53 loss creates therapeutic vulnerability in colorectal cancer

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    • Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

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      Crystal structures of three forms of Toll-like receptor (TLR) 9 — unliganded or bound either to immune stimulatory CpG-containing DNA or inhibitory DNA — together reveal the molecular basis of TLR9 activation.

    • The octahaem MccA is a haem c–copper sulfite reductase

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      Sulfite-reducing microbes couple the reduction of sulfite to the generation of a proton motive force that sustains organismic growth; here, two X-ray crystal structures are solved of MccA, a c-type cytochrome enzyme with eight haem groups that catalyses the six-electron reduction of sulfite to sulfide at a novel haem–copper active site.


    • Corrigendum: Deterministic direct reprogramming of somatic cells to pluripotency

      • Yoach Rais
      • Asaf Zviran
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      • Ohad Gafni
      • Elad Chomsky
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      • Abed AlFatah Mansour
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      • Itay Maza
      • Nofar Mor
      • Dror Baran
      • Leehee Weinberger
      • Diego A. Jaitin
      • David Lara-Astiaso
      • Ronnie Blecher-Gonen
      • Zohar Shipony
      • Zohar Mukamel
      • Tzachi Hagai
      • Shlomit Gilad
      • Daniela Amann-Zalcenstein
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      • Noa Novershtern
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    • Corrigendum: Derivation of novel human ground state naive pluripotent stem cells

      • Ohad Gafni
      • Leehee Weinberger
      • Abed AlFatah Mansour
      • Yair S. Manor
      • Elad Chomsky
      • Dalit Ben-Yosef
      • Yael Kalma
      • Sergey Viukov
      • Itay Maza
      • Asaf Zviran
      • Yoach Rais
      • Zohar Shipony
      • Zohar Mukamel
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      • Shay Geula
      • Inbal Caspi
      • Dan Schneir
      • Tamar Shwartz
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      • Daniela Amann-Zalcenstein
      • Sima Benjamin
      • Ido Amit
      • Amos Tanay
      • Rada Massarwa
      • Noa Novershtern
      • Jacob H. Hanna