The identification of the enzyme plasmin as a defence against cancer cells that have spread to the brain, and of tumour-cell serpin proteins that inhibit plasmin production, outlines a mechanism for the formation of brain metastases.
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Erler, J. Disabling defences in the brain. Nature 508, 46–47 (2014). https://doi.org/10.1038/508046a
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DOI: https://doi.org/10.1038/508046a
