Whistle-blowers risk a huge personal backlash in exposing scientific misconduct (see, for example, 26; 2014), but they can hope to correct only a tiny percentage of the published literature. Nature 505,
Since 1980, when MEDLINE started categorizing retractions, there have been 6,119 retracted papers, amounting to 0.03% of the 17.8 million published. Even if the majority of these retractions arise from misconduct (see, for example, et al. Proc. Natl Acad. Sci. USA http://doi.org/jf5; 2012), this still affects only a very small proportion of the literature overall.
From alarming estimates derived from studies by Bayer (712; 2011) and Amgen ( et al. Nature Rev. Drug Discov. 10, 531–533; 2012) that some 60–70 and Nature 483, % of biomedical research papers may contain irreproducible results, it would seem that our time would be better spent investigating experimental irreproducibility rather than hunting down fraudsters.