Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Structural biology

Ion channel seen by electron microscopy

Structures of the heat-sensitive TRPV1 ion channel have been solved using single-particle electron cryo-microscopy, representing a landmark in the use of this technique for structural biology. See Articles p.107 & p.113

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: TRPV1 in closed and open states.

References

  1. Venkatachalam, K. & Montell, C. Annu. Rev. Biochem. 76, 387–417 (2007).

    Article  CAS  Google Scholar 

  2. Liao, M., Cao, E., Julius, D. & Cheng, Y. Nature 504, 107–112 (2013).

    Article  ADS  CAS  Google Scholar 

  3. Cao, E., Liao, M., Cheng, Y. & Julius, D. Nature 504, 113–118 (2013).

    Article  ADS  CAS  Google Scholar 

  4. Caterina, M. J. et al. Nature 389, 816–824 (1997).

    Article  ADS  CAS  Google Scholar 

  5. Popot, J.-L. et al. Annu. Rev. Biophys. 40, 379–408 (2011).

    Article  CAS  Google Scholar 

  6. Li, X. et al. Nature Meth. 10, 584–590 (2013).

    Article  CAS  Google Scholar 

  7. Bai, X. C., Fernandez, I. S., McMullan, G. & Scheres, S. H. W. eLife 2, e00461 (2013).

    Article  Google Scholar 

  8. Scheres, S. H. W. J. Struct. Biol. 180, 519–530 (2012).

    Article  CAS  Google Scholar 

  9. Mio, K. et al. J. Mol. Biol. 367, 373–383 (2007).

    Article  CAS  Google Scholar 

  10. Moiseenkova-Bell, V. Y., Stanciu, L. A., Serysheva, I. I., Tobe, B. J. & Wensel, T. G. Proc. Natl Acad. Sci. USA 105, 7451–7455 (2008).

    Article  ADS  CAS  Google Scholar 

  11. Long, S. B., Tao, X., Campbell, E. B. & MacKinnon, R. Nature 450, 376–382 (2007).

    Article  ADS  CAS  Google Scholar 

  12. Clayton, G. M. et al. Proc. Natl Acad. Sci. USA 105, 1511–1515 (2008).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard Henderson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Henderson, R. Ion channel seen by electron microscopy. Nature 504, 93–94 (2013). https://doi.org/10.1038/504093a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/504093a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing