Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Developmental neuroscience

Miniature human brains

Nature volume 501, pages 319–320 (2013)Cite this article

Subjects

A study shows that stem cells can be used to generate self-organizing three-dimensional tissues that mimic the developing human brain. These tissues provide a tool for modelling neurodevelopmental disorders. See Article p.373

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Organoid generation from human pluripotent stem cells.
Figure 2: A detailed view.

Notes

  1. *This article and the paper under discussion1 were published online on 28 August 2013.

References

  1. Lancaster, M. A. et al. Nature 501, 373–379 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Gaspard, N. et al. Nature 455, 351–357 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Eiraku, M. et al. Cell Stem Cell 3, 519–532 (2008).

    Article  CAS  Google Scholar 

  4. Eiraku, M. et al. Nature 472, 51–56 (2011).

    Article  ADS  CAS  Google Scholar 

  5. Nasu, M. et al. PLoS ONE 7, e53024 (2012).

    Article  ADS  CAS  Google Scholar 

  6. Nakano, T. et al. Cell Stem Cell 10, 771–785 (2012).

    Article  CAS  Google Scholar 

  7. Sasai, Y. Nature 493, 318–326 (2013).

    Article  ADS  CAS  Google Scholar 

  8. Mariani, J. et al. Proc. Natl Acad. Sci. USA 109, 12770–12775 (2012).

    Article  ADS  CAS  Google Scholar 

  9. Takahashi, K. et al. Cell 131, 861–872 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Oliver Brüstle is at the Life & Brain Centre, University of Bonn, 53105 Bonn, Germany.,

    Oliver Brüstle

Authors
  1. Oliver Brüstle
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Oliver Brüstle.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brüstle, O. Miniature human brains. Nature 501, 319–320 (2013). https://doi.org/10.1038/nature12552

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12552

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing