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HIV

Integration triggers death

Nature volume 498, pages 305–306 (2013)Cite this article

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That HIV cripples the immune system by killing CD4+ T cells has long been known. It now emerges that the protein DNA-PK, activated by viral integration into the host-cell genome, is the agent of this death response. See Letter p.376

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Figure 1: Opposing responses to DNA damage.

Notes

  1. *This article and the paper under discussion1 were published online on 5 June 2013.

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  1. Anna Marie Skalka is at the Fox Chase Cancer Centre, Philadelphia, Pennsylvania 19111, USA.,

    Anna Marie Skalka

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  1. Anna Marie Skalka
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Correspondence to Anna Marie Skalka.

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Skalka, A. Integration triggers death. Nature 498, 305–306 (2013). https://doi.org/10.1038/nature12254

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