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Biochemistry

Oxidation controls the DUB step

Nature volume 497, pages 49–50 (2013)Cite this article

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Reversible oxidation of amino-acid residues can directly regulate the activity of cellular enzymes. This principle has now been extended to deubiquitinating enzymes, with implications for cell signalling and protein turnover.

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Figure 1: Redox regulation of deubiquitinating enzymes (DUBs).

References

  1. Paulsen, C. E. & Carroll, K. S. ACS Chem. Biol. 5, 47–62 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Kulathu, Y. et al. Nature Commun. 4, 1569 (2013).

    Article  ADS  Google Scholar 

  3. Lee, J. G., Baek, K., Soetandyo, N. & Ye, Y. Nature Commun. 4, 1568 (2013).

    Article  ADS  Google Scholar 

  4. Tonks, N. K. Cell 121, 667–670 (2005).

    Article  CAS  PubMed  Google Scholar 

  5. Komander, D., Clague, M. J. & Urbe, S. Nature Rev. Mol. Cell Biol. 10, 550–563 (2009).

    Article  CAS  Google Scholar 

  6. Enesa, K. et al. J. Biol. Chem. 283, 18582–18590 (2008).

    Article  CAS  PubMed  Google Scholar 

  7. Cotto-Rios, X. M., Bekes, M., Chapman, J., Ueberheide, B. & Huang, T. T. Cell Rep. 2, 1475–1484 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. Michael J. Clague is in the Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool L69 3BX, UK.,

    Michael J. Clague

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  1. Michael J. Clague
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Correspondence to Michael J. Clague.

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Clague, M. Oxidation controls the DUB step. Nature 497, 49–50 (2013). https://doi.org/10.1038/497049a

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