The activity of G-protein-coupled receptors is not limited to the cell surface. Evidence from microscopy points to three temporally, spatially and perhaps functionally distinct waves of signalling by these receptors. See Letter p.534
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Notes
*This article and the paper under discussion4 were published online on 20 March 2013.
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Lohse, M., Calebiro, D. Receptor signals come in waves. Nature 495, 457–458 (2013). https://doi.org/10.1038/nature12086
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DOI: https://doi.org/10.1038/nature12086
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