Table of Contents

Japanese Table of Contents

Volume 489 Number 7416 pp335-466

20 September 2012

About the cover

High-resolution maps of genome-wide gene expression have been available for mice for a few years, but only relatively coarse equivalents have been published for the human brain because of the challenges presented by the 1,000-fold increase in size and the limited availability and quality of postmortem tissue. Now Michael Hawrylycz and colleagues at the Allen Institute for Brain Science in Seattle, Washington, have used laser microdissection and microarrays to assess 900 precise subdivisions in brains from two healthy men with 60,000 gene-expression probes. The resulting atlas, freely available at www.brain-map.org, allows comparisons between humans and other animals, and will facilitate studies of human neurological and psychiatric diseases. One early observation from the data is a human-specific pattern — compared with the mouse and rhesus monkey — for the calcium-binding protein CALB1 in the hippocampus. Cover image: Benjamin Facer & Josh Royall/Allen Institute for Brain Science.

This Week

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World View

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Seven Days

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Books and Arts

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  • Military Science: The USSR's deadly secret

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Obituary

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Q&As

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Futures

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Brief Communications Arising

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Articles

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    • Christian F. Beckmann
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    Laser microdissection and microarrays are used to assess 900 precise subdivisions of the brains from three healthy men with 60,000 gene expression probes; the resulting atlas allows comparisons between humans and other animals, and will facilitate studies of human neurological and psychiatric diseases.

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Letters

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  • Structure of the haptoglobin–haemoglobin complex

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    This study reports the crystal structure of porcine haptoglobin in complex with haemoglobin at 2.9Åresolution; this provides a structural basis of haptoglobin-mediated recognition of haemoglobin, and insight into the protective role of haptoglobin at the atomic level.

Errata

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