Table of Contents

Japanese Table of Contents

Volume 483 Number 7390 pp373-504

22 March 2012

About the cover

The cover shows a detail from Through the Looking Glass, a large-scale glass artwork by TED Fellow Kate Nichols, which uses silver nanoparticles as 'paint'. The colours arise from oscillations of electrons in the metal particles, called localized surface plasmon resonances. The plasmonic properties of these particles make them attractive for a variety of imaging, sensing and renewable-energy technologies. But it is the particles less than 10 nanometres in diameter that may be most relevant to many natural and engineered systems. As particles approach the quantum regime, our knowledge of how their plasmonic properties change becomes rather hazy. Jonathan Scholl and colleagues investigate the plasmonic properties of individual silver nanoparticles with dimensions in the quantum size regime. Using electron microscopy and spectroscopy, they correlate a particle's plasmon resonance with its size and geometry for diameters ranging from 20 nm to less than 2 nm. The results demonstrate the quantum-mechanical nature of small metallic nanospheres, with direct applications to catalytically active and biologically relevant nanoparticles. Cover credit: Kate Nichols, Alivisatos Lab, Univ. California, Berkeley, Photo: Donald Felton.

This Week


  • Incidental benefits

    Scientists who screen the genes of volunteers for research should tell participants if they find information relevant to their health.

  • Flight risk

    As the campaign against animal research intensifies, so must the response.

  • Mass appeal

    As physicists close in on the Higgs boson, they should resist calls to change its name.

World View


Seven Days

  • Seven days: 16–22 March 2012

    The week in science: Neutrinos don't travel faster than light; China cracks down on research misconduct; and protest over Spanish science cuts.

News in Focus




  • Neuroscience: Observatories of the mind

    An ambitious project to map the mouse brain at the Allen Institute for Brain Science is a huge undertaking that may unify neuroscience, argue Christof Koch and R. Clay Reid.

  • Physics: A century of cosmic rays

    High-energy nuclei coming from far beyond the Solar System, and the exotic particles they produce, remain our best window onto the extreme Universe. Michael Friedlander reflects on what we have learned.

Books and Arts

  • Climate science: At the storm front

    Simon Lewis gets to grips with a climate scientist's account of a conflict that began with a graph.

    • Review of The Hockey Stick and the Climate Wars: Dispatches from the Front Lines
      Michael E. Mann
  • Nutrition: Chew on this

    Anthony King savours a surreally varied show on food, from glowing sushi to 1,001 uses for a pig carcass.

    • Review of Edible: The Taste of Things to Come
  • Q&A: The maths raconteur

    Barry Mazur, a mathematician at Harvard University in Cambridge, Massachusetts, has explored the literary side of mathematics. With the publication this month of Circles Disturbed, a collection of essays on mathematics and narrative that he edited with writer Apostolos Doxiadis, he talks about the overlapping realms of mathematics and the imagination.

    • Review of Circles Disturbed: The Interplay of Mathematics and Narrative
      Apostolos Doxiadis & Barry Mazur





  • Postdoc or not?

    Life-sciences graduates interested in academic research typically need to do at least one postdoc. For physics students, there are multiple caveats to consider.

    • Karen Kaplan



Career Briefs


naturejobs job listings and advertising features






  • Resonant quantum transitions in trapped antihydrogen atoms

    • C. Amole
    • M. D. Ashkezari
    • M. Baquero-Ruiz
    • W. Bertsche
    • P. D. Bowe
    • E. Butler
    • A. Capra
    • C. L. Cesar
    • M. Charlton
    • A. Deller
    • P. H. Donnan
    • S. Eriksson
    • J. Fajans
    • T. Friesen
    • M. C. Fujiwara
    • D. R. Gill
    • A. Gutierrez
    • J. S. Hangst
    • W. N. Hardy
    • M. E. Hayden
    • A. J. Humphries
    • C. A. Isaac
    • S. Jonsell
    • L. Kurchaninov
    • A. Little
    • N. Madsen
    • J. T. K. McKenna
    • S. Menary
    • S. C. Napoli
    • P. Nolan
    • K. Olchanski
    • A. Olin
    • P. Pusa
    • C. Ø. Rasmussen
    • F. Robicheaux
    • E. Sarid
    • C. R. Shields
    • D. M. Silveira
    • S. Stracka
    • C. So
    • R. I. Thompson
    • D. P. van der Werf
    • J. S. Wurtele

    These authors demonstrate resonant quantum transitions in a pure antimatter atom—antihydrogen—by using microwave radiation to flip the spin of the positron of an anti-atom in a magnetic trap, thus ejecting the anti-atom.

  • Electron tomography at 2.4-ångström resolution

    • M. C. Scott
    • Chien-Chun Chen
    • Matthew Mecklenburg
    • Chun Zhu
    • Rui Xu
    • Peter Ercius
    • Ulrich Dahmen
    • B. C. Regan
    • Jianwei Miao

    An electron tomography method is demonstrated that can determine the three-dimensional structure of a gold nanoparticle at 2.4 Å resolution, including the locations of some of the individual atoms within the sample.

  • Adaptive radiation of multituberculate mammals before the extinction of dinosaurs

    • Gregory P. Wilson
    • Alistair R. Evans
    • Ian J. Corfe
    • Peter D. Smits
    • Mikael Fortelius
    • Jukka Jernvall

    Adaptive radiation of Mesozoic-era multituberculate mammals began at least 20 million years before the extinction of non-avian dinosaurs and continued across the Cretaceous–Paleogene boundary—probably as a result of dietary expansion towards herbivory during the ecological rise of angiosperms—and is supported by increases in generic richness and disparity in dental complexity and body size.

  • IDH mutation impairs histone demethylation and results in a block to cell differentiation

    • Chao Lu
    • Patrick S. Ward
    • Gurpreet S. Kapoor
    • Dan Rohle
    • Sevin Turcan
    • Omar Abdel-Wahab
    • Christopher R. Edwards
    • Raya Khanin
    • Maria E. Figueroa
    • Ari Melnick
    • Kathryn E. Wellen
    • Donald M. O’Rourke
    • Shelley L. Berger
    • Timothy A. Chan
    • Ross L. Levine
    • Ingo K. Mellinghoff
    • Craig B. Thompson

    Cancer-associated IDH mutants that produce 2-hydroxyglutarate are shown to prevent the histone demethylation that is required for lineage-specific progenitor cells to differentiate into terminally differentiated cells.

  • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

    • Sevin Turcan
    • Daniel Rohle
    • Anuj Goenka
    • Logan A. Walsh
    • Fang Fang
    • Emrullah Yilmaz
    • Carl Campos
    • Armida W. M. Fabius
    • Chao Lu
    • Patrick S. Ward
    • Craig B. Thompson
    • Andrew Kaufman
    • Olga Guryanova
    • Ross Levine
    • Adriana Heguy
    • Agnes Viale
    • Luc G. T. Morris
    • Jason T. Huse
    • Ingo K. Mellinghoff
    • Timothy A. Chan

    Mutation of isocitrate dehydrogenase 1 (IDH1) is shown to induce DNA hypermethylation and to remodel the epigenome to resemble that of gliomas with the CpG island methylator phenotype.

  • Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

    • Peppi Koivunen
    • Sungwoo Lee
    • Christopher G. Duncan
    • Giselle Lopez
    • Gang Lu
    • Shakti Ramkissoon
    • Julie A. Losman
    • Päivi Joensuu
    • Ulrich Bergmann
    • Stefan Gross
    • Jeremy Travins
    • Samuel Weiss
    • Ryan Looper
    • Keith L. Ligon
    • Roel G. W. Verhaak
    • Hai Yan
    • William G. Kaelin Jr

    The (R)-enantiomer of 2-hydroxyglutarate, which is produced when IDH is mutated in human tumours, is shown to stimulate the activity of the EGLN prolyl 4-hydroxylases, leading to diminished levels of HIF and enhanced human astrocyte proliferation.