Table of Contents

Japanese Table of Contents

Volume 482 Number 7386 pp439-562

23 February 2012

About the cover

The English mathematician Alan Turing was born on 23 June 1912 and died tragically aged only 41, yet his influence is still felt in many fields. In this issue marking the centenary of Turing’s birth, Nature hails him as one of the top scientific minds of all time (see pages 440 and 441). Computer specialists and those working in fields that have exploited computer science — including Sydney Brenner (page 461) and Henry Markram (page 456) — explain some aspects of this remarkable legacy. For more, go to www.nature.com/turing. Cover image: Andy Potts; Turing family.

This Week

Editorials

Top
  • Turing at 100

    This year marks the centenary of the birth of Alan Turing. He deserves your attention.

  • Over the line

    Dishonesty, however tempting, is the wrong way to tackle climate sceptics.

World View

Top
  • The man behind the machine

    Alan Turing is famous for many reasons. Andrew Hodges delves into why Turing's achievements took so long to be recognized.

Seven Days

Top
  • Seven days: 17–23 February 2012

    The week in science: Animals saved from chemical safety tests; fund launched to clean up methane and black-carbon emissions; and excitement over nanopore DNA sequencing.

News in Focus

Features

Top

comment

Books and Arts

Top
  • Infectious disease: Chronicles of a killer virus

    Just over 30 years after HIV/AIDS was first recognized, three accounts of its ravages intrigue Robin Weiss.

    • Review of The AIDS Conspiracy: Science Fights Back The Origins of AIDS AIDS at 30: A History
      Nicoli Nattrass Jacques Pepin & Victoria A. Harden
  • Q&A: The eternal optimist

    Peter Diamandis is the founder of the non-profit X Prize Foundation, which aims to kick-start research and development to solve humanity's biggest challenges. On the publication this week of his book Abundance, co-authored with journalist Steven Kotler, he explains how technological and social progress will enable us to provide enough food, water and energy for all.

    • Review of Abundance: The Future Is Better Than You Think
      Peter H. Diamandis & Steven Kotler

Careers

Features

Top
  • Education: Outside the box

    A European industrial doctorate could help students to break out of academia, but applied science is not for everyone.

    • Quirin Schiermeier

Q&As

Top

naturejobs job listings and advertising features

Futures

research

Brief Communications Arising

Top

Perspectives

Top
  • The case for open computer programs

    • Darrel C. Ince
    • Leslie Hatton
    • John Graham-Cumming

    Scientific reproducibility now very often depends on the computational method being available to duplicate, so here it is argued that all source code should be freely available.

Articles

Top
  • Structural basis of highly conserved ribosome recycling in eukaryotes and archaea

    • Thomas Becker
    • Sibylle Franckenberg
    • Stephan Wickles
    • Christopher J. Shoemaker
    • Andreas M. Anger
    • Jean-Paul Armache
    • Heidemarie Sieber
    • Charlotte Ungewickell
    • Otto Berninghausen
    • Ingo Daberkow
    • Annette Karcher
    • Michael Thomm
    • Karl-Peter Hopfner
    • Rachel Green
    • Roland Beckmann

    Cryo-electron-microscopy reconstructions of eukaryotic and archaeal ribosomes bound by ABCE1 and Pelota suggest a conserved mechanism for ribosome recycling.

Letters

Top
  • Wetting of flexible fibre arrays

    • C. Duprat
    • S. Protière
    • A. Y. Beebe
    • H. A. Stone

    The parameters critical in determining the behaviour of a fibrous medium wetted with a single liquid drop are identified as fibre flexibility, fibre geometry and drop volume.

    See also
  • The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

    • Nan Liu
    • Michael Landreh
    • Kajia Cao
    • Masashi Abe
    • Gert-Jan Hendriks
    • Jason R. Kennerdell
    • Yongqing Zhu
    • Li-San Wang
    • Nancy M. Bonini

    The conserved microRNA miR-34 regulates age-associated events and long-term brain integrity in Drosophila, providing a molecular link between ageing and neurodegeneration.

  • Maintenance of muscle stem-cell quiescence by microRNA-489

    • Tom H. Cheung
    • Navaline L. Quach
    • Gregory W. Charville
    • Ling Liu
    • Lidia Park
    • Abdolhossein Edalati
    • Bryan Yoo
    • Phuong Hoang
    • Thomas A. Rando

    Adult muscle stem cells are used as a model system to show that the microRNA pathway, and specifically miR-489, is essential for the maintenance of the quiescent state of an adult stem-cell population by suppressing a key proliferation factor, Dek.

  • Clonal selection drives genetic divergence of metastatic medulloblastoma

    • Xiaochong Wu
    • Paul A. Northcott
    • Adrian Dubuc
    • Adam J. Dupuy
    • David J. H. Shih
    • Hendrik Witt
    • Sidney Croul
    • Eric Bouffet
    • Daniel W. Fults
    • Charles G. Eberhart
    • Livia Garzia
    • Timothy Van Meter
    • David Zagzag
    • Nada Jabado
    • Jeremy Schwartzentruber
    • Jacek Majewski
    • Todd E. Scheetz
    • Stefan M. Pfister
    • Andrey Korshunov
    • Xiao-Nan Li
    • Stephen W. Scherer
    • Yoon-Jae Cho
    • Keiko Akagi
    • Tobey J. MacDonald
    • Jan Koster
    • Martin G. McCabe
    • Aaron L. Sarver
    • V. Peter Collins
    • William A. Weiss
    • David A. Largaespada
    • Lara S. Collier
    • Michael D. Taylor

    In a mouse model and in human medulloblastoma patients, the metastases in an individual have similar genomic alterations and DNA methylation patterns, but these patterns are highly divergent from those of the primary tumour, indicating that therapies will need to be tailored to fit the molecular alterations present in the primary tumour and/or the metastases.

    See also
  • DCC constrains tumour progression via its dependence receptor activity

    • Marie Castets
    • Laura Broutier
    • Yann Molin
    • Marie Brevet
    • Guillaume Chazot
    • Nicolas Gadot
    • Armelle Paquet
    • Laetitia Mazelin
    • Loraine Jarrosson-Wuilleme
    • Jean-Yves Scoazec
    • Agnès Bernet
    • Patrick Mehlen

    A mouse model is developed in which the pro-apoptotic activity of DCC is silenced and the mice are more prone to intestinal tumour progression, giving insight into the role of DCC in human colorectal cancer.

  • Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

    • Paul Krimpenfort
    • Ji-Ying Song
    • Natalie Proost
    • John Zevenhoven
    • Jos Jonkers
    • Anton Berns

    In a mouse model of mammary carcinoma, loss of deleted in colorectal cancer (DCC) promotes metastasis formation, and in cell cultures derived from p53-deficient mouse mammary tumours DCC expression controls netrin-1-dependent cell survival, supporting the function of DCC as a context-dependent tumour suppressor that limits survival of disseminated tumour cells.

  • The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

    • Jing Huang
    • Buddha Gurung
    • Bingbing Wan
    • Smita Matkar
    • Natalia A. Veniaminova
    • Ke Wan
    • Juanita L. Merchant
    • Xianxin Hua
    • Ming Lei

    Crystal structures of menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1–LEDGF heterodimer, show that menin contains a deep pocket that binds short peptides of MLL1 or JUND in the same manner, but produces opposite effects on transcription.

  • Structure and dynamics of the M3 muscarinic acetylcholine receptor

    • Andrew C. Kruse
    • Jianxin Hu
    • Albert C. Pan
    • Daniel H. Arlow
    • Daniel M. Rosenbaum
    • Erica Rosemond
    • Hillary F. Green
    • Tong Liu
    • Pil Seok Chae
    • Ron O. Dror
    • David E. Shaw
    • William I. Weis
    • Jürgen Wess
    • Brian K. Kobilka

    The X-ray crystal structure of the M3 muscarinic acetylcholine receptor bound to the bronchodilator drug tiotropium is reported; comparison of this structure with that of the M2 muscarinic acetylcholine receptor reveals key differences that could potentially be exploited to develop subtype-selective drugs.

    See also