Table of Contents

Japanese Table of Contents

Volume 482 Number 7385 pp275-434

16 February 2012

About the cover

The channelrhodopsins are light-gated ion channels, found in algae, that have rapidly become familiar in the neuroscience lab as optogenetics reagents: the activities of neurons expressing channelrhodopsins can be optically controlled within systems as complicated as living mammals. The X-ray crystal structure of a chimaera of two channelrhodopsins has now been determined at 2.3 Å resolution. The structure reveals the molecular architecture of this ion channel, including the retinal-binding pocket and cation conduction pathway. This work paves the way for the design of new channelrhodopsin variants with enhanced properties. Cover image: Hiroshi M. Sasaki.

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    Channelrhodopsins are light-gated cation channels used in optogenetics; here, the high-resolution crystal structure of a channelrhodopsin from Chlamydomonas reinhardtii is determined.

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