Table of Contents

Japanese Table of Contents

Volume 481 Number 7381 pp237-404

19 January 2012

About the cover

Philanthropic research funding has become increasingly important in recent years, but much of it comes at a cost: charities rarely pay the full overheads of research, and agenda-driven funding sources may skew research priorities. In a Comment piece, Patrick Aebischer argues that universities should levy 'full economic costs' in their dealings with charities in order to cover additional expenses such as buildings, maintenance and staff. Cover art: 2&3 Illustration.

This Week

Editorials

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  • Antarctic Treaty is cold comfort

    Researchers need to cement the bond between science and the South Pole if the region is to remain one of peace and collaboration.

  • Face up to fraud

    The UK government and funding agencies must address research misconduct.

  • Cap in hand

    A word to the wise on getting that much-needed research funding.

World View

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Seven Days

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  • Seven days: 13–19 January 2012

    The week in science: US authorities crack down on plagiarism; failed Mars probe splashes down in the Pacific; and chemical firm BASF shifts its transgenic plant operations out of Europe.

News in Focus

Features

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comment

Books and Arts

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  • Fiction: Cosmic creation

    Pedro Ferreira explores Alan Lightman's latest novel — a magical-reality take on the origins of the Universe.

    • Review of Mr g: A Novel About the Creation
      Alan Lightman
  • Antarctica: Scientists to the end

    Colin Martin celebrates a London exhibition revealing the research legacy of Robert Scott's final journey.

    • Review of Scott's Last Expedition

Correspondence

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Obituary

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Careers

Features

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  • Outreach: Field hospitality

    Hosting guests on research trips can give scientists a chance to showcase their work — but it can also cause distractions.

    • Lucas Laursen

Career Briefs

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naturejobs job listings and advertising features

Futures

research

Insight: Frontiers in biology

Insight: Frontiers in biology

Review

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  • The Amazon basin in transition

    • Eric A. Davidson
    • Alessandro C. de Araújo
    • Paulo Artaxo
    • Jennifer K. Balch
    • I. Foster Brown
    • Mercedes M. C. Bustamante
    • Michael T. Coe
    • Ruth S. DeFries
    • Michael Keller
    • Marcos Longo
    • J. William Munger
    • Wilfrid Schroeder
    • Britaldo S. Soares-Filho
    • Carlos M. Souza Jr
    • Steven C. Wofsy

    A synthesis of recent research shows that the effects of human actions have already altered the regional hydrology and energy balance of parts of the Amazon basin, and that interactions between deforestation, fire and climate change are likely to further alter carbon storage, precipitation patterns and river discharge.

Articles

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  • A novel retinoblastoma therapy from genomic and epigenetic analyses

    • Jinghui Zhang
    • Claudia A. Benavente
    • Justina McEvoy
    • Jacqueline Flores-Otero
    • Li Ding
    • Xiang Chen
    • Anatoly Ulyanov
    • Gang Wu
    • Matthew Wilson
    • Jianmin Wang
    • Rachel Brennan
    • Michael Rusch
    • Amity L. Manning
    • Jing Ma
    • John Easton
    • Sheila Shurtleff
    • Charles Mullighan
    • Stanley Pounds
    • Suraj Mukatira
    • Pankaj Gupta
    • Geoff Neale
    • David Zhao
    • Charles Lu
    • Robert S. Fulton
    • Lucinda L. Fulton
    • Xin Hong
    • David J. Dooling
    • Kerri Ochoa
    • Clayton Naeve
    • Nicholas J. Dyson
    • Elaine R. Mardis
    • Armita Bahrami
    • David Ellison
    • Richard K. Wilson
    • James R. Downing
    • Michael A. Dyer

    The retinoblastoma genome is shown to be stable, but multiple cancer pathways are identified that are epigenetically deregulated, providing potential new therapeutic targets.

    See also
  • Structure of HDAC3 bound to co-repressor and inositol tetraphosphate

    • Peter J. Watson
    • Louise Fairall
    • Guilherme M. Santos
    • John W. R. Schwabe

    The crystal structure of histone deacetylase HDAC3 bound to the co-repressor SMRT is reported, and suggests that inositol tetraphosphate could act as a regulator of HDAC3; this has therapeutic implications, because HDACs are emerging targets of anti-cancer drugs.

Letters

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  • Coherent singlet-triplet oscillations in a silicon-based double quantum dot

    • B. M. Maune
    • M. G. Borselli
    • B. Huang
    • T. D. Ladd
    • P. W. Deelman
    • K. S. Holabird
    • A. A. Kiselev
    • I. Alvarado-Rodriguez
    • R. S. Ross
    • A. E. Schmitz
    • M. Sokolich
    • C. A. Watson
    • M. F. Gyure
    • A. T. Hunter

    Exploiting the weak interactions between electron spins and nuclear spins in silicon-based quantum dots leads to a dephasing time two orders of magnitude greater than in analogous gallium-arsenide-based devices, demonstrating the potential of silicon as a host material for quantum information processing.

  • Reconfigurable self-assembly through chiral control of interfacial tension

    • Thomas Gibaud
    • Edward Barry
    • Mark J. Zakhary
    • Mir Henglin
    • Andrew Ward
    • Yasheng Yang
    • Cristina Berciu
    • Rudolf Oldenbourg
    • Michael F. Hagan
    • Daniela Nicastro
    • Robert B. Meyer
    • Zvonimir Dogic

    Molecular chirality can be used to control interfacial tension in multi-component mixtures of chiral molecules, and tuning the chirality makes it possible to produce and manipulate self-assembling complex chiral structures.

    See also
  • Kimberlite ascent by assimilation-fuelled buoyancy

    • James K. Russell
    • Lucy A. Porritt
    • Yan Lavallée
    • Donald B. Dingwell

    Assimilation of mantle minerals is proposed as a cause of deep-seated exsolution of dissolved volatiles and the driver of kimberlite magma ascent.

  • Recovery rates reflect distance to a tipping point in a living system

    • Annelies J. Veraart
    • Elisabeth J. Faassen
    • Vasilis Dakos
    • Egbert H. van Nes
    • Miquel Lürling
    • Marten Scheffer

    Decreased rates of recovery from perturbations, or critical slowing down, are demonstrated in a living system, indicating that recovery rates can be used to probe the resilience of complex systems.

  • Global landscape of HIV–human protein complexes

    • Stefanie Jäger
    • Peter Cimermancic
    • Natali Gulbahce
    • Jeffrey R. Johnson
    • Kathryn E. McGovern
    • Starlynn C. Clarke
    • Michael Shales
    • Gaelle Mercenne
    • Lars Pache
    • Kathy Li
    • Hilda Hernandez
    • Gwendolyn M. Jang
    • Shoshannah L. Roth
    • Eyal Akiva
    • John Marlett
    • Melanie Stephens
    • Iván D’Orso
    • Jason Fernandes
    • Marie Fahey
    • Cathal Mahon
    • Anthony J. O’Donoghue
    • Aleksandar Todorovic
    • John H. Morris
    • David A. Maltby
    • Tom Alber
    • Gerard Cagney
    • Frederic D. Bushman
    • John A. Young
    • Sumit K. Chanda
    • Wesley I. Sundquist
    • Tanja Kortemme
    • Ryan D. Hernandez
    • Charles S. Craik
    • Alma Burlingame
    • Andrej Sali
    • Alan D. Frankel
    • Nevan J. Krogan

    Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions between human proteins and human immunodeficiency virus proteins.

  • Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection

    • Stefanie Jäger
    • Dong Young Kim
    • Judd F. Hultquist
    • Keisuke Shindo
    • Rebecca S. LaRue
    • Eunju Kwon
    • Ming Li
    • Brett D. Anderson
    • Linda Yen
    • David Stanley
    • Cathal Mahon
    • Joshua Kane
    • Kathy Franks-Skiba
    • Peter Cimermancic
    • Alma Burlingame
    • Andrej Sali
    • Charles S. Craik
    • Reuben S. Harris
    • John D. Gross
    • Nevan J. Krogan

    The transcription cofactor CBF-β is shown to regulate the ability of HIV-1 to evade host restriction mediated by the deaminase APOBEC3; it acts by interacting with the HIV protein Vif, so disrupting the Vif–CBF-β interaction could provide a new therapeutic target against HIV-1 infection.

  • Reductive carboxylation supports growth in tumour cells with defective mitochondria

    • Andrew R. Mullen
    • William W. Wheaton
    • Eunsook S. Jin
    • Pei-Hsuan Chen
    • Lucas B. Sullivan
    • Tzuling Cheng
    • Youfeng Yang
    • W. Marston Linehan
    • Navdeep S. Chandel
    • Ralph J. DeBerardinis

    Tumour cells with defective mitochondria are found to use glutamine-dependent reductive carboxylation, rather than oxidative metabolism, as the major pathway of citrate and lipid formation.

  • Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

    • Caryn S. Ross-Innes
    • Rory Stark
    • Andrew E. Teschendorff
    • Kelly A. Holmes
    • H. Raza Ali
    • Mark J. Dunning
    • Gordon D. Brown
    • Ondrej Gojis
    • Ian O. Ellis
    • Andrew R. Green
    • Simak Ali
    • Suet-Feung Chin
    • Carlo Palmieri
    • Carlos Caldas
    • Jason S. Carroll

    Genome-wide mapping of oestrogen receptor-α binding sites in primary breast cancer tissues shows that oestrogen receptor binding is dynamically regulated and that the expression of genes near differentially bound regulatory regions is associated with clinical outcome.

    See also