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Cancer

A drug-resistant duo

The efficacy of the anticancer drug vemurafenib, which is used to treat metastatic melanoma, is plagued by acquired resistance. A picture of how such resistance develops is emerging. See Letter p.387

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Figure 1: The two faces of oncogenic B-RAF.

References

  1. Bollag, G. et al. Nature 467, 596–599 (2010).

    Article  ADS  CAS  Google Scholar 

  2. Chapman, P. B. et al. N. Engl. J. Med. 364, 2507–2516 (2011).

    Article  CAS  Google Scholar 

  3. Flaherty, K. T. et al. N. Engl. J. Med. 363, 809–819 (2010).

    Article  CAS  Google Scholar 

  4. Poulikakos, P. I. et al. Nature 480, 387–390 (2011).

    Article  ADS  CAS  Google Scholar 

  5. Gray-Schopfer, V., Wellbrock, C. & Marais, R. Nature 445, 851–857 (2007).

    Article  ADS  CAS  Google Scholar 

  6. Wellbrock, C., Karasarides, M. & Marais, R. Nature Rev. Mol. Cell Biol. 5, 875–885 (2004).

    Article  CAS  Google Scholar 

  7. Udell, C. M., Rajakulendran, T., Sicheri, F. & Therrien, M. Cell. Mol. Life Sci. 68, 553–565 (2011).

    Article  CAS  Google Scholar 

  8. Wagle, N. et al. J. Clin. Oncol. 29, 3085–3096 (2011).

    Article  CAS  Google Scholar 

  9. Johannessen, C. M. et al. Nature 468, 968–972 (2010).

    Article  ADS  CAS  Google Scholar 

  10. Nazarian, R. et al. Nature 468, 973–977 (2010).

    Article  ADS  CAS  Google Scholar 

  11. Kobayashi, S. et al. N. Engl. J. Med. 352, 786–792 (2005).

    Article  CAS  Google Scholar 

  12. Nardi, V., Azam, M. & Daley, G. Q. Curr. Opin. Hematol. 11, 35–43 (2004).

    Article  CAS  Google Scholar 

  13. Poulikakos, P. I., Zhang, C., Bollag, G., Shokat, K. M. & Rosen, N. Nature 464, 427–430 (2010).

    Article  ADS  CAS  Google Scholar 

  14. Heidorn, S. J. et al. Cell 140, 209–221 (2010).

    Article  CAS  Google Scholar 

  15. Hatzivassiliou, G. et al. Nature 464, 431–435 (2010).

    Article  ADS  CAS  Google Scholar 

Download references

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Correspondence to Marc Therrien.

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Lavoie, H., Therrien, M. A drug-resistant duo. Nature 480, 329–330 (2011). https://doi.org/10.1038/480329a

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