Caspase-1 is one of the main culprits behind sepsis, a form of systemic inflammation. The related enzyme caspase-11 is also involved, but the relative roles of the two proteins have been confusing, until now. See Letter p.117
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References
Martin, G. S. et al. N. Engl. J. Med. 348, 1546–1554 (2003).
Kayagaki, N. et al. Nature 479, 117–121 (2011).
Fuentes-Prior, P. & Salvesen, G. S. Biochem. J. 384, 201–232 (2004).
Green, D. R. Means to an End: Apoptosis and Other Cell Death Mechanisms (Cold Spring Harbor Lab. Press, 2011).
Schroder, K. & Tschopp, J. Cell 140, 821–832 (2010).
Li, P. et al. Cell 80, 401–411 (1995).
Wang, S. et al. Cell 92, 501–509 (1998).
Lamkanfi, M. et al. Blood 113, 2742–2745 (2009).
Lamkanfi, M. et al. J. Immunol. 185, 4385–4392 (2010).
Keane, T. M. et al. Nature 477, 289–294 (2011).
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Green, D. A heavyweight knocked out. Nature 479, 48–50 (2011). https://doi.org/10.1038/479048a
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DOI: https://doi.org/10.1038/479048a
